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  </channel><item rdf:about="https://www.devdiscourse.com/article/headlines/2506762-fire-engulfs-private-pharma-lab-in-visakhapatnam-after-reactor-explosion-7-injured">
    <title>Fire engulfs private pharma lab in Visakhapatnam after reactor explosion, 7 injured</title>
    <dc:date>2023-07-01T10:40:45+00:00</dc:date>
    <link>https://www.devdiscourse.com/article/headlines/2506762-fire-engulfs-private-pharma-lab-in-visakhapatnam-after-reactor-explosion-7-injured</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[As many as seven people were injured after a fire broke out in a private pharmaceutical lab in Atchutapuram Industrial Special Economic Zone, in the Anakapalli locality of Visakhapatnam, police said on Friday. "At about 11:10 am, in a pharmaceutical lab, when a solvent was being loaded into a container, some short circuit occurred and the solvent exploded. There were 35 people working, and 7 were injured. The injured have been shifted to the hospital," ASP PSN Rao, Anakapalli told ANI.
[{852cfdfb-cfc3-4bf3-a0ec-004422cfbc91:intradmin/ANI-20230630120903.jpg}] "Precautionary measures are being taken and the fire tenders are here. The fire will be brought under control, ' he added.
Upon receiving information about the fire, police teams and fire tenders rushed to the site. The fire was caused due to a sudden reactor blast, according to the Superintendent of Police, Anakapalli Murali Krishna.
District Fire Officer, Lakshman Rao, said that eight fire tenders rushed to the spot and four more are on the way. The operation is still underway, as the fire is still not doused at the lab.
]]></description>
<dc:subject>India laboratory explosion injury drugs pharmaceutical solvent</dc:subject>
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<item rdf:about="https://cen.acs.org/safety/industrial-safety/Massachusetts-plant-explosion-kills-1/101/web/2023/05">
    <title>Massachusetts plant explosion kills 1</title>
    <dc:date>2023-05-06T11:28:03+00:00</dc:date>
    <link>https://cen.acs.org/safety/industrial-safety/Massachusetts-plant-explosion-kills-1/101/web/2023/05</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[An explosion at a Seqens chemical plant in Newburyport, Massachusetts, early on Thursday, May 4, killed one worker. The cause of the explosion has not been determined.
The incident is the third serious accident at the plant, which manufactures pharmaceutical chemicals under contract, since 2020 when an explosion damaged a building. A chemical fire occurred at the site in 2021.
The body of Jack O’Keefe, an employee at the company for more than 25 years according to a local news report, was removed from the site late Thursday afternoon. Four other workers on site when the explosion occurred were hospitalized for precautionary reasons, but were uninjured, according to Barry Salt, Newburyport deputy fire chief.
“They had just wrapped up a typical manufacturing procedure that they’d done numerous times daily,” Salt says. “Obviously there was some sort of accident to cause the explosion, but what that was or how that happened is still in the beginning stages of investigation.”
The plant manufactures both active ingredients and intermediates of pharmaceutical chemicals. Chemicals on site at the time of the accident, according to Salt, included acetone, isopropyl alcohol, and methanol.
Salt says air quality has been monitored by the Massachusetts Department of Fire Services beginning 1.5 h after the explosion. Local residents have been informed that there is no risk in the area.
The area of the plant damaged in the explosion has been in operation for more than 20 years. The facility was built in the 1980s. Novacap, a French firm now called Seqens, became the site’s owner when it bought PCI Synthesis in 2018.
]]></description>
<dc:subject>us_MA industrial explosion death acetone drugs methanol pharmaceutical</dc:subject>
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<item rdf:about="https://www.eastcoastdaily.in/2022/12/27/4-people-killed-in-a-fire-at-a-andhra-pradeshs-pharma-lab.html">
    <title>DH Latest News, DH NEWS, Latest News, death, NEWS , Andhra Pradesh, Fire Accident, 4 people killed, pharma lab.</title>
    <dc:date>2022-12-28T11:37:28+00:00</dc:date>
    <link>https://www.eastcoastdaily.in/2022/12/27/4-people-killed-in-a-fire-at-a-andhra-pradeshs-pharma-lab.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[ flash fire in a room in a manufacturing block of Indian pharmaceutical company Laurus Labs’ plant in Visakhapatnam resulted in the deaths of four of its employees, the company reported on Tuesday.

According to Laurus, ‘one more worker is receiving medical attention in a hospital as a result of the incident that happened on Monday night.’

Without providing any other information on the occurrence, the company, which specialises in anti-retroviral, hepatitis C, and oncology drugs, said it had started an investigation.

Laurus reported that all of its other production units were operating regularly and that it did not anticipate any significant effects on its business.

]]></description>
<dc:subject>India industrial fire injury drugs pharmaceutical</dc:subject>
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<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.2c00330">
    <title>Nitrosamine Risk Assessments in Oligonucleotides</title>
    <dc:date>2022-12-27T11:45:29+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.2c00330</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[The European Medicines Agency, the U.S. Food and Drug Administration, and other regulatory agencies expect that all pharmaceutical products be assessed for the potential presence of N-nitrosoamine (nitrosamine) impurities. This white paper addresses general considerations for nitrosamine risk assessments of oligonucleotide products. The authors propose a general risk assessment platform which should facilitate safe, consistent development of new treatments and alignment with regulatory expectations.

]]></description>
<dc:subject>laboratory discovery environmental pharmaceutical</dc:subject>
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<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.2c00263">
    <title>Experimental Versus Predicted Heats of Reaction for Some Common Reaction Types in Pharmaceutical Industry</title>
    <dc:date>2022-11-14T11:46:28+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.2c00263</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Common pharmaceutical reactions were modeled using the commercially available CHETAH program and the novel TCIT program to obtain heats of reaction values. The programs were used to predict thermochemical data for isolated molecules based on their functional groups. Both programs use group theory, CHETAH, commercially available through ASTM and TCIT using a more modern approach and under development at Purdue. Reactions such as amide coupling (via both uronium reagent and T3P), debenzylation, bromination, tert-butyloxycarbonyl deprotection, Suzuki couplings, and halogenation were analyzed. These values were then compared to experimental values to assess the accuracy of each program’s predictions. Experimental values were provided by several pharmaceutical companies, who participated and advised in this endeavor, as listed in Acknowledgements. Deviations were on average within ±20% of experimental values for both programs, but outlier behavior with respect to certain functional groups was distinct. CHETAH calculations were at times hampered by missing groups, which was not the case for TCIT, which is designed to be arbitrarily extensible. This project resulted in a broader molecular library for TCIT, exposure of shortcomings in CHETAH, and strategies to improve accuracy moving forward.

]]></description>
<dc:subject>laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
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<item rdf:about="https://www.kptv.com/2022/10/25/portland-fire-hazmat-team-responds-after-lab-fire-raises-concern/">
    <title>Portland Fire HazMat team responds after lab fire raises concern</title>
    <dc:date>2022-10-25T10:40:37+00:00</dc:date>
    <link>https://www.kptv.com/2022/10/25/portland-fire-hazmat-team-responds-after-lab-fire-raises-concern/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[PORTLAND Ore. (KPTV) – A HazMat team was deployed on Monday after Portland Fire & Rescue responded to a fire at Lacamas Labs, a producer of pharmaceutical intermediates.

Portland fire crews first received reports of the warehouse fire around 4:30 in the 3600 block of N Suttle Road. Responding crews reported seeing a large smoke column from a distance and were told the building was in the process of evacuation when they arrived.

Plant workers informed crews of the hazardous materials inside the building adjacent where the fire was active. Because of the dangerous materials, a HazMat team was called to the scene.


Portland Fire HazMat team responds after lab fire raises concern.(Portland Fire & Rescue)
Arriving crews found fire showing from the front of the building in and around the area of the oil pump. Early reports indicate that a failed hot oil system used in their operations caused the fire.

After a targeted attack on the exterior of the building, Portland fire said a more “methodical” approach was taken for the interior because of the hazardous materials. Crews faced concern with the risk of putting water onto substances that behave violently with water.

When entering the building, firefighters used gas monitoring devices to ensure the premises were safe. On entry, they discovered much of the fire was contained to the outside of the structure with very little damage to the inside of the warehouse.]]></description>
<dc:subject>us_OR laboratory fire response pharmaceutical</dc:subject>
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<item rdf:about="https://www.chemistryworld.com/news/contaminated-cough-syrup-linked-to-66-child-deaths-in-the-gambia/4016373.article">
    <title>Contaminated cough syrup linked to 66 child deaths in The Gambia</title>
    <dc:date>2022-10-16T10:31:43+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/contaminated-cough-syrup-linked-to-66-child-deaths-in-the-gambia/4016373.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Indian generics firm Maiden Pharmaceuticals has been implicated in the deaths of 66 children in The Gambia, West Africa.

On 5 October, the World Health Organization (WHO) issued a special alert focusing on four substandard cough syrups: Promethazine oral solution, Kofexmalin Baby Cough Syrup, Makoff Baby Cough Syrup and Magrip N Cold Syrup, all manufactured by Maiden, which is based in the north Indian state of Haryana. These products are ‘potentially linked with acute kidney injuries and 66 deaths among children’ in The Gambia, the report states. ‘WHO recommends all countries detect and remove these products from circulation to prevent further harm to patients,’ director general Tedros Ghebreyesus stated.

Toxic ethylene glycol and dietheylene glycol were discovered in samples taken from the implicated cough syrups, which are often used to treat children
According to the WHO, at the end of July 2022, the Gambian government received information about an increase in acute kidney injuries among young children from Edward Francis Small Teaching Hospital, the country’s main hospital. By 30 September, 78 cases had been reported including 66 deaths. About 72% of these cases were under two years old, reported from six out of the country’s seven health regions.

The link with cough syrups was discovered after samples of medicines used by the children were sent to labs in Senegal and Ghana – since The Gambia has no such facilities. Testing identified toxic contaminants diethylene glycol and ethylene glycol. The government began recalling the products from 2 October and has banned further sales. A door-to-door search aims to recover those already distributed and the police are investigating. More than 16,000 products have been located and confiscated for destruction. The Gambia’s President Adama Barrow has stated that his country will go to the bottom of this tragedy and is negotiating with the World Bank to create testing facilities.]]></description>
<dc:subject>Gambia public discovery death ethylene_glycol illegal pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:291caffdb142/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Gambia"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:ethylene_glycol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:illegal"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.est.2c02896#">
    <title>Rethinking Subthreshold Effects in Regulatory Chemical Risk Assessments</title>
    <dc:date>2022-10-06T14:27:22+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.est.2c02896#</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A great number of dose–response studies indicate that hormesis is a common phenomenon, occurring in numerous organisms exposed to singular or combined environmental stressors, such as pharmaceuticals, heavy metals, micro/nanoplastics, organic flame retardants, pesticides, and rare earths. (1−6) While biological responses to low exposure levels are often beneficial, exposure to doses below the no-observed-adverse-effect-level (NOAEL; hereafter subthreshold doses) does not always translate to beneficial responses. (2,4) For example, subthreshold contaminant doses can enhance the virulence of phytopathogenic microbes and promote the resistance of crop pests with significant implications for crop production. (2,7,8) Subthreshold contaminant exposures can also stimulate infectious animal/human pathogens and promote their resistance to antibiotics and other drugs, threatening long-term sustainability. Importantly, the hormetic function of common pathways that regulate cancer progress indicate that current regulatory standards may not protect adequately against cancer risks. (9−11)

Current risk assessment frameworks used around the world to assess exposure and effects are largely based on scientific developments from the mid to late 20th century, which frequently included only very high (often environmentally unrealistic) doses and the broad assumption of linearity in the response in the absence of evidence of alternative dose–response relationships (Figure 1). (12−16) How representative and realistic this approach is increasingly being challenged, in a modern era of analytical advances enabling measurement of low doses and hormetic responses. An expanding scientific literature provides evidence of significant effects of subthreshold contaminant doses on numerous animals, plants, and microbes. (1−6) We opine that regulatory risk assessments on exposure and effects should not be based upon outdated science and biologically unsupported assumptions regarding linearity. Instead, subthreshold effects and dose–response behavior should be included in the regulatory risk assessment. We urge for this approach to be adopted as part of a more real-life risk simulation approach, (17) especially in recognition of the growing evidence of genotoxicity of chemicals such as fluoride and arsenic. (18,19)

]]></description>
<dc:subject>public discovery environmental ag_chems drugs metals pesticides pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:bfa94c8032e4/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:ag_chems"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:drugs"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:metals"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pesticides"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.thehindu.com/news/national/telangana/fire-at-pharma-lab-in-hyderabad/article65798694.ece">
    <title>Fire at pharma lab in Hyderabad </title>
    <dc:date>2022-08-23T10:06:23+00:00</dc:date>
    <link>https://www.thehindu.com/news/national/telangana/fire-at-pharma-lab-in-hyderabad/article65798694.ece</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A major fire broke out at a pharmaceutical laboratory located in IDA Jeedimetla on Monday. Seven workers suffered minor injuries in the incident.

According to the Jeedimetla police, the incident took place at Sridhara Laboratories Private Limited around 9.30 a.m., when workers were processing chemicals. Seven of the injured workers were shifted to emergency care, and they were all stable.

Locals reported that there was a loud explosion and soon fire and billowing smoke engulfed the facility. Part of the laboratory, including infrastructure, was also gutted in the incident.

Fire service personnel pressed four fire tenders into action and carried out a long operation to put out the fire.

]]></description>
<dc:subject>India laboratory explosion injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:9d3f5c75166a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.fiercepharma.com/manufacturing/pharma-plant-explosions-india-kills-three-workers">
    <title>Pharma plant explosion in India kills 3 workers</title>
    <dc:date>2022-07-14T11:06:37+00:00</dc:date>
    <link>https://www.fiercepharma.com/manufacturing/pharma-plant-explosions-india-kills-three-workers</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[For the second time in eight weeks, there have been deaths tied to an explosion at a pharmaceutical manufacturing facility, this time in India.

Three workers were killed instantly when the boiler they were working on at Pusilin Biotechnology Private exploded, the Xinhua News Agency reported. The plant is in Haryana, near New Delhi.

According to the Chinese Embassy in India, two of the engineers were Chinese and one was Indian, the news agency reported.

It was in April that 10 workers died of smoke inhalation caused by an explosion and fire at a Chinese drug manufacturing plant. The explosion at the Qilu Tianhe Huishi Pharmaceutical Co. facility in eastern Shandong province was caused by sparks as workers welded a pipe under the plant.]]></description>
<dc:subject>India industrial explosion death pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:8d551daf71e2/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.globaltimes.cn/page/202206/1268489.shtml">
    <title>Beijing and Shanghai launch inspections of hazardous chemical companies after fire at Shanghai ethylene glycol plant</title>
    <dc:date>2022-06-20T10:27:24+00:00</dc:date>
    <link>https://www.globaltimes.cn/page/202206/1268489.shtml</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Emergency authorities in China's two metropolises, Beijing and Shanghai, decided to carry out citywide inspections of hazardous chemical companies from Sunday to identify potential risks, after a fire caused by a dangerous chemical explosion in Shanghai.

The fire broke out Saturday morning at an ethylene glycol plant area operated by Sinopec Shanghai Petrochemical Company, a subsidiary of China's largest state-owned petrochemical enterprise Sinopec, killing one person and injuring another slightly.

There was a loud explosion followed by a pungent smell, before the whole plant was engulfed in black smoke, local media quoted residents nearby as saying.

Sinopec Shanghai Petrochemical Company on Sunday expressed deep condolences to the victims of the fire and expressed deep sympathy to the injured and the families of the victims, as cleanup work is underway.

The inspections mainly involve dangerous chemical manufacturers, oil depots, gas stations in key areas, chemical companies, pharmaceutical manufacturers and other operators with storage facilities, Beijing emergency authorities said in a statement.]]></description>
<dc:subject>China industrial follow-up environmental ethylene_glycol pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:10c3f6a4b896/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:China"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:ethylene_glycol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.china.org.cn/china/2022-05/25/content_78235644.htm">
    <title>China steps up efforts to control new pollutants- China.org.cn</title>
    <dc:date>2022-05-25T10:43:57+00:00</dc:date>
    <link>http://www.china.org.cn/china/2022-05/25/content_78235644.htm</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[China has announced moves to intensify its battle against new pollutants to improve environmental protection.

Generated in the production or use of hazardous chemicals such as pesticides, these new pollutants include persistent organic pollutants, endocrine disruptors, and antibiotics. Such pollution poses risks to the environment and human health but is not currently effectively treated in the country.

The State Council has recently released an action plan to strengthen the control of new pollutants. It vowed to improve the country's treatment capacity significantly by 2025.

Specifically, China will complete the risk screening of some major chemicals, dynamically release lists of new pollutants under control, and implement control measures, including bans and emission caps. Laws and systems on the risk management of hazardous chemicals will be gradually established and improved.

The official document listed measures in six areas, including system-building, research and monitoring, clean production and green manufacturing, and technological support.]]></description>
<dc:subject>China public discovery environmental pesticides pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:37e22adedcc0/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:China"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pesticides"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://waynetimes.com/news/williamson-thatcher-chemical-and-surrounding-area-evacuated-for-building-fire/">
    <title>Williamson Thatcher Chemical and surrounding area evacuated for building fire</title>
    <dc:date>2022-03-27T10:07:21+00:00</dc:date>
    <link>https://waynetimes.com/news/williamson-thatcher-chemical-and-surrounding-area-evacuated-for-building-fire/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A call to 911 at 7 a.m. on Wednesday (3/23) concerning an active fire at the Thatcher Chemical plant at 4135 Route 104 in Williamson resulted in 12 fire companies and medical personnel responding.

According to First Assistant Williamson Fire Chief John Manahan, the fire erupted in a 70x40  room where large plastic bins were stored for cleaning before reuse. The large 300 gallon tanks did have remnants of chemicals use in processing of products for water treatment, food manufacturing, and pharmaceuticals.

“There might residual in some of the drums in some amounts but there is nothing in the area that burned was an area of concern.”

Williamson firefighters constantly train in the Thatcher facility and were aware of the room’s contents.

When initial Williamson crews arrived, the fire was already through the roof and a heavy black smoke filled the area. Nearby businesses were closed and people were told to stay indoors.

]]></description>
<dc:subject>us_NY industrial fire injury pharmaceutical water_treatment</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:7ea54feb5dd1/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_NY"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:water_treatment"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.edinburghlive.co.uk/news/edinburgh-news/edinburgh-chemical-plant-workers-rushed-23122651">
    <title>Edinburgh chemical plant workers rushed to hospital following emergency incident</title>
    <dc:date>2022-02-17T11:23:31+00:00</dc:date>
    <link>https://www.edinburghlive.co.uk/news/edinburgh-news/edinburgh-chemical-plant-workers-rushed-23122651</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Three people have been hospitalised as a result of an emergency incident at an Edinburgh pharmaceutical plant.

Emergency crews rushed to the scene at the MacFarlan Smith facility on Wheatfield Road following reports of a serious issue on Wednesday afternoon.

At least eight vehicles from Police Scotland, the Scottish Ambulance Service and the Scottish Fire and Rescue Service (SFRS) attended the incident, according to eyewitnesses.

One told Edinburgh Live a chemical spill had caused a mass response, but that is now understood not to be the case.

Three workers have since been rushed to hospital as a precautionary measure while an internal investigation is underway.

Officers blocked off access to the plant shortly after the incident while specialist teams were dispatched, however the nature of the emergency has not been disclosed.

]]></description>
<dc:subject>United_Kingdom industrial release injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:579c0b79d0cd/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:release"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/news/extent-of-pharmaceutical-pollution-on-every-continent-on-earth-revealed/4015238.article">
    <title>Extent of pharmaceutical pollution on every continent on Earth revealed</title>
    <dc:date>2022-02-16T11:50:11+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/extent-of-pharmaceutical-pollution-on-every-continent-on-earth-revealed/4015238.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[The global extent of pharmaceutical pollution has been revealed in a new study that has also shone a spotlight on contamination hotspots around the world. A lab in York in the UK worked with samples from 259 rivers, encompassing 104 countries on every continent to build-up a picture of contamination of waterways with drugs.

‘This is the first time, using one huge dataset, we are able to take a comparative view of pharmaceutical pollution across the world,’ says John Wilkinson at the University of York, UK, where water samples were shipped by collaborators for high-performance liquid chromatography-mass spectrometry. The survey involved the cooperation of 86 institutions worldwide, with a consortium of 127 researchers. Previously, extensive data on pharma pollution was only available for the US, Europe and China.

Samples were collected at 1052 locations, including 36 countries not previously studied, and screened for 61 active pharmaceutical ingredients (APIs). Each partner collecting samples followed the same protocol and samples were analysed on one instrument using the same method. The most contaminated sites were in sub-Saharan Africa, south Asia and South America. Waterway pollution is the result of production, disposal or human use of pharmaceuticals.

]]></description>
<dc:subject>United_Kingdom laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:d8aabedd1029/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://ec.europa.eu/environment/news/zero-pollution-drinking-water-endocrine-disrupting-chemicals-new-watch-list-pollutants-2022-01-19_en">
    <title>Zero pollution in drinking water: endocrine disrupting chemicals on new watch list of pollutants</title>
    <dc:date>2022-01-20T11:10:29+00:00</dc:date>
    <link>https://ec.europa.eu/environment/news/zero-pollution-drinking-water-endocrine-disrupting-chemicals-new-watch-list-pollutants-2022-01-19_en</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Following a decision by the Commission today, drinking water across the EU will have to be monitored more closely for the potential presence of two endocrine disrupting compounds (beta-estradiol and nonylphenol) throughout the whole water supply chain. As required by EU rules on drinking water in force since last year, the Commission established today a first ‘watch list’ of emerging compounds to monitor and address if needed. 

Commissioner for Environment, Oceans and Fisheries Virginijus Sinkevičius said:

There can be no compromise on the quality standards for our tap water. Today we are giving effect to new rules that not only prevent well-known pollutants but also give us tools to address emerging concerns. We start with two substances that are endocrine disruptors affecting our health, the environment and biodiversity.

Now that the watch list is established, Member States have until 12 January 2023 to put in place monitoring requirements throughout the drinking water supply chain, as well as take measures if guidance values are exceeded. Over time, if new substances emerge that are likely to be present in drinking water and could pose a potential health risk—such as endocrine disruptors, pharmaceuticals or microplastics—the Commission will add them to the list. This new mechanism will contribute to achieving the objectives of the EU Chemicals StrategySearch for available translations of the preceding link••• and of the Zero Pollution Action PlanSearch for available translations of the preceding link••• for a toxic-free environment. ]]></description>
<dc:subject>Europe public discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:2e3c1d8cc6ab/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Europe"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/news/four-dead-in-boiler-explosion-at-indian-chemical-plant/4015018.article">
    <title>Four dead in boiler explosion at Indian chemical plant</title>
    <dc:date>2022-01-07T11:30:44+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/four-dead-in-boiler-explosion-at-indian-chemical-plant/4015018.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Four people, including a four-year-old girl and her mother, were killed when a boiler exploded at a manufacturing plant run by Canton Laboratories in Gujarat, India, on 24 December. 11 others were injured, including another child, according to local news reports.

The cause of the boiler explosion is being investigated. The blast destroyed temporary units that the company had put up a few metres away from the boiler complex. While listed as storage in plans, it transpires that employees and their families were living there, in violation of local regulations. The mother and daughter were inside when the units collapsed. The other two victims were operators in the boiler room.

On 25 December, two directors of Canton Laboratories were arrested and charged with culpable homicide not amounting to murder. The company makes fine and speciality chemicals, supplying a range of industries from pharmaceuticals to electronics and photography.

This is the third deadly incident at chemicals facilities in Gujarat in December 2021, after one person was killed at RP industries on 7 December, and five died in an explosion at Gujarat Fluorochemicals on 16 December.]]></description>
<dc:subject>India industrial follow-up death drugs pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:be49d34f7369/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:drugs"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00375">
    <title>An Investigation into the Unexpected Corrosion of Nickel Alloy Vessels with Selectfluor</title>
    <dc:date>2021-12-14T11:41:44+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00375</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Selectfluor is one of the most widely used fluorinating agents in the pharmaceutical industry. These reactions are often scaled up in reactors made with corrosion-resistant metals such as Hastelloy because of the presence of fluoride in Selectfluor. Herein we report an investigation into the variable performance of a fluorination reaction in the belzutifan synthesis, which initially focused on the unexpected corrosiveness of the reaction toward the high-nickel alloys Hastelloy C-276 (N10276) and Hastelloy C-22 (N06022). This investigation identified that the corrosion, rather than being inherent to the reaction, was associated with the particular lot of Selectfluor used and could be correlated with elevated levels of chloride and iron in the lot of Selectfluor. Further investigation found that the increased aggressiveness was associated with the elevated chloride level (some chloride can be found in nearly all lots of Selectfluor), and the presence of metals does not impact the level of corrosion. A corrosion-reaction pathway involving the presence of an oxidized chloride species is proposed which accounts for both the poor reaction performance and the corrosion observed.

]]></description>
<dc:subject>us_NJ industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:dbf3b5f1b33e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_NJ"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://timesofindia.indiatimes.com/city/nashik/man-killed-as-fire-breaks-out-in-pharma-company-in-ahmednagar/articleshow/88192929.cms">
    <title>Man killed as fire breaks out in pharma company in Ahmednagar</title>
    <dc:date>2021-12-10T11:05:27+00:00</dc:date>
    <link>https://timesofindia.indiatimes.com/city/nashik/man-killed-as-fire-breaks-out-in-pharma-company-in-ahmednagar/articleshow/88192929.cms</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Nashik: A man was killed after a fire broke out in a pharmaceutical company in Ahmednagar on Wednesday night.
The incident took place at 10 pm after which two fire tenders rushed to the spot. The fire, which was reported in the chemical storage of the company, was doused off and the operation was called off at 1 am by the fire brigade.
The fire brigade officials, that carried out the search, found a body of a person which was partially burnt. The police said the man was about 40 years of age. His body was taken to a civil hospital to conduct the post mortem.
“Currently, there are no details of the man’s identity. A case of accidental death has been registered with the police station and the investigations are being carried out,” said the MIDC police station officials.
The cause of the fire is yet to be ascertained, said the officials from the fire brigade adding that it is likely due to a short circuit.]]></description>
<dc:subject>India industrial fire death pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:ffd71260dca1/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00296">
    <title>Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances</title>
    <dc:date>2021-12-04T11:55:11+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00296</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Appropriate control of impurities from all sources is critically important during the development of a pharmaceutical product. One class of impurity that has gained considerable attention over the past few years is extractables and leachables. We report a model for assessment of the risk posed by leachable impurities for a small-molecule drug substance. The first step of this study consists of a high-level assessment of the risk posed by leachable impurities in the drug substance, by taking into account the drug product’s route of administration. In the case of parenteral route of administration, a more comprehensive process-specific second step risk assessment is typically warranted. This second step consists of risk assessment of polymer component(s) for the potential to release leachable impurities, risk scoring, and classification. For high-risk components, risk mitigation studies can be performed in step 3, such as leachable impurity removal via component pre-flush with the process solvent, extractables’ studies under harsher conditions, and toxicity assessments.

]]></description>
<dc:subject>us_IL industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:a16c3a3c5974/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_IL"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00368">
    <title>An Optimized Safe Process from Bench to Pilot cGMP Production of API Eptifibatide Using a Multigram-Scale Microwave-Assisted Solid-Phase Peptide Synthesizer</title>
    <dc:date>2021-11-27T12:28:18+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00368</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A growing industrial interest toward the peptide drug market fueled the need for the development of effective and cGMP compliant manufacturing methods for these complex molecules. Solid-phase strategies are considered methods of election for medium-length peptide syntheses not only on the research scale but for multigram-scale production, as well. The possibility to use microwave-assisted technology on the multigram scale, recently introduced, prompted us to evaluate the possibility to conveniently set up a safe and fully cGMP-compliant pilot process to produce eptifibatide, a generic peptide active pharmaceutical ingredient. Accordingly, we developed an optimized process on the laboratory scale (1–5 mmol), which was subsequently successfully scaled up to 70 mmol, obtaining all the information required by regulatory agencies to validate the process and qualify the pilot scale plant. The process consists of 5 steps: (1) automated microwave-assisted solid-phase synthesis of eptifibatide linear precursor; (2) cleavage from the resin with concomitant amino acid side-chains deprotection; (3) disulfide-bond formation in solution; (4) purification by flash column chromatography; (5) ion-exchange solid-phase extraction. Since the direct scale-up of a multigram-scale cGMP compliant peptide API production procedure is a challenge that requires an accurate understanding of each involved step, we initially performed a quality management risk assessment, which enabled a smooth and effective achievement of a successful final result.

]]></description>
<dc:subject>Italy laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:0e63354fe211/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Italy"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00360">
    <title>MSD’s Process Safety Scale-Up Methodology for Pilot Plant Scale and Beyond</title>
    <dc:date>2021-11-11T11:46:14+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00360</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Process safety testing is critical for small molecule active pharmaceutical ingredient (API) scale-up and manufacturing by proactively identifying any process safety hazards, including environmental and industrial hygiene issues. The intent of this contribution is to describe how Merck & Co., Inc. Kenilworth, NJ (known as MSD outside of the U.S. and Canada) manages process safety testing for pilot plant and manufacturing scale operations with a stagewise approach. Several case studies will be discussed.

]]></description>
<dc:subject>industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:85d48aa5648a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.raps.org/news-and-articles/news-articles/2021/10/fda-chastises-three-us-firms-for-ignoring-record-r">
    <title>FDA chastises three US firms for ignoring record requests, inadequate CMO oversight, and shoddy resp</title>
    <dc:date>2021-10-22T11:00:02+00:00</dc:date>
    <link>https://www.raps.org/news-and-articles/news-articles/2021/10/fda-chastises-three-us-firms-for-ignoring-record-r</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[FDA’s 30 September warning letter to Marcus Research Laboratory found “significant deviations from current good manufacturing practice (CGMP) violations for active pharmaceutical ingredients (APIs)” in its manufacturing of povidone iodine (PVP-I) used for presurgical preparations. The warning letter followed inspections conducted in May.
 
The firm failed to adequately investigate the effect of temperature excursions on the quality of an API following a fire and use of an extinguisher.
 
During production, personnel observed PVP-I in a reactor cabinet that was “smoldering” and responded to an “imminent fire” by using a fire extinguisher. The API was subjected to “inconsistent temperature exposure and additional processing and hold times.” Yet the firm only tested the affected drums to determine the amount of iodine that was still present in the material and released them for further processing.
 
A similar situation occurred in August 2020 when production personnel observed a “smoking” reactor cabinet in the facility. Production stopped and the materials were “held in unknown conditions,” according to the letter. “Your firm again, solely tested the affected drums of material for percent available iodine and released them for further processing” after this second incident, noted FDA.
 
“In both instances, your firm created deviation reports but released drugs based solely on composite results of percent available iodine,” wrote the agency. “Your drugs were exposed to excess heat, fire, smoke, and debris. Additional contaminants or other particulates from the use of the fire extinguisher may have also compromised the material.”
]]></description>
<dc:subject>us_MO laboratory follow-up environmental fire_extinguisher pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:79774c835eb5/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MO"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire_extinguisher"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.thehindu.com/news/cities/bangalore/three-workers-injured-in-explosion-at-chemical-factory/article36660899.ece">
    <title>Three workers injured in explosion at chemical factory</title>
    <dc:date>2021-09-25T10:35:44+00:00</dc:date>
    <link>https://www.thehindu.com/news/cities/bangalore/three-workers-injured-in-explosion-at-chemical-factory/article36660899.ece</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Three workers were injured when a solvent vessel exploded accidentally within the premises of a chemical factory in Attibele Industrial Area on Friday. The blast resulted in a chemical leak which in turn released a pungent odour within a radius of several hundred metres. The incident comes after two fire accidents in the city in the last four days.

The blast occurred at Lake Chemicals Pvt. Ltd., a pharmaceutical-related plant, at around 1.05 p.m. “Eight workers were at the spot when the solvent vessel burst, splattering chemicals around. Two workers sustained significant injuries, while another person sustained minor injuries,” said Mallesh, Deputy Superintendent of Police, Bengaluru Rural. The injured have been identified as Gnanavelu, 22, and Mune Gowda, 30, who, according to sources, suffered significant burns — up to 30%. A third worker, Suryanath, 27, escaped with minor injuries. The injured are being treated at a private hospital nearby and are said to be out of danger.

“When we reached the spot, the injured had already been shifted to hospitals but there was a fire raging, which we put out using two fire tenders,” said P.M. Nagesh, District Fire Officer, who led the operation at the factory. “The vessel was about eight feet high and eight feet wide. It had chemicals such as toluene, methanol, and hydrochloric acid. While we don’t yet know the exact reason for the blast, unregulated pressure or temperature may have led to an adverse reaction and blast,” he said.]]></description>
<dc:subject>India industrial explosion injury pharmaceutical solvent</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:437384b2fe7c/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:solvent"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00197">
    <title>Predicting the Fire and Explosion Properties of Early-Phase Active Pharmaceutical Ingredients</title>
    <dc:date>2021-09-11T10:56:13+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00197</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Early-phase drug product (DP) manufacture from an active pharmaceutical ingredient (API) is often performed in the absence of fire and explosion data, as material for testing either does not exist or cannot be spared. This leads to onerous processing restrictions, as properties are assumed to be “worst case” or processes are run with an inadequate basis of safety, leading to accidents. Full testing for fire and explosion properties uses about 800 g of material. This paper discusses predictive methodologies used by GSK R&D based on chemistry knowledge and experiments using <1 g of material to identify “materials of concern” (e.g., low minimum ignition energy or adverse dust explosion properties) that require additional safety measures or accelerated testing. The methodology has been employed on over 20 compounds in GSK R&D.

]]></description>
<dc:subject>laboratory discovery environmental dust pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:32955727c1af/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:dust"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://finance.yahoo.com/news/shared-lab-spaces-pharma-life-174607776.html">
    <title>Shared Lab Spaces in Pharma &amp; Life Sciences: Know Your EHS Risks</title>
    <dc:date>2021-09-10T10:24:05+00:00</dc:date>
    <link>https://finance.yahoo.com/news/shared-lab-spaces-pharma-life-174607776.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Pharmaceutical, life science, and biotech incubators and accelerators are designed to assist with the growth and success of companies by providing various types of business support and resources. Specifically, incubators are companies formed in the "idea" stage and need assistance from the ground-up. Accelerators, on the other hand, need assistance in progressing their business. Both incubators and accelerators often require support from established companies such as a physical place to work, shared laboratory spaces, capital, and networking connections.

Shared laboratory spaces are a popular option for pharmaceutical and life science start-up organizations to allow them a physical space to work and provide various types of business resources, including environmental, health, and safety (EHS) support. EHS responsibilities fall to the employer, however, the tenant or the landlord may take ownership depending on each contractual agreement. This makes communication between the landlord and tenant crucial. All lease agreements will vary as an incubator or accelerator, but below are a few common EHS risks to consider when operating a shared laboratory space.

]]></description>
<dc:subject>laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:3ebc7d2d3990/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.bostonglobe.com/2021/06/16/metro/newburyport-pharmaceutical-plant-ordered-stop-operations-after-2-chemical-fires/?event=event12">
    <title>Newburyport pharmaceutical plant ordered to stop operations after 2 chemical fires</title>
    <dc:date>2021-06-17T10:04:34+00:00</dc:date>
    <link>https://www.bostonglobe.com/2021/06/16/metro/newburyport-pharmaceutical-plant-ordered-stop-operations-after-2-chemical-fires/?event=event12</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Newburyport pharmaceutical plant ordered to stop operations after 2 chemical fires

A pharmaceutical plant in Newburyport has been shut down while the fire department investigates the cause of a chemical fire, the second such fire at the plant in just over a year, officials said.

The two-alarm fire at Segens/PCI Synthesis broke out Friday afternoon in the production workshop area of the plant. A Tier 1 hazmat incident was declared, due to the chemicals stored and used in the building at 9 Opportunity Way, according to the fire department.

Fire Chief Christopher LeClaire said, “The company is cooperating fully with the Newburyport Fire Department. We look forward to working with the company to ensure the safety of the employees and nearby residents in the future.”

“Production operations are currently stopped until the investigation is completed together with local authorities,” a spokesperson for the company confirmed.

Employees and contractors were on site when the fire started. Everyone was evacuated, and the emergency processes and sprinkler system “worked as expected,” the spokesperson said.

No injuries were reported, the fire department said.

The site had another fire and a Tier 2 Hazmat incident last February when at least six explosions from a chemical production room tore a large hole in its roof, according to the department.]]></description>
<dc:subject>us_MA industrial follow-up environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:764b24955652/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://whdh.com/news/pharmaceutical-plant-fire-prompts-large-emergency-response-chemical-scare/">
    <title>Pharmaceutical plant fire prompts large emergency response, chemical scare – Boston News, Weather, Sports</title>
    <dc:date>2021-06-12T12:20:41+00:00</dc:date>
    <link>https://whdh.com/news/pharmaceutical-plant-fire-prompts-large-emergency-response-chemical-scare/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[NEWBURYPORT, MASS. (WHDH) - A fire that ignited within a pharmaceutical plant in Newburyport Friday prompted a chemical scare and a large emergency response.

Firefighters were called to the PCI Synthesis/Seqens plant located at 9 Opportunity Way around 5:30 p.m. and upon their arrival found heavy smoke coming from a number of roof vents and declared it to be a chemical fire, according to a release issued by the department.

The fire was knocked down in about 20 minutes.

Due to the chemicals stored and used in the building, a Tier 1 Hazmat incident was declared. The specialists determined there was not threat to the public.


The Massachusetts Department of Environmental Protection responded to the scene.

No injureis were reported.

The cause of the fire is under investigation.

]]></description>
<dc:subject>us_MA industrial fire response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:d95edfb91a0f/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.businessinsurance.com/article/20210521/STORY/912341991/Chemical-firms-suffers-over-$7-million-damage-from-factory-fire">
    <title>Chemical firms suffers over $7 million damage from factory fire</title>
    <dc:date>2021-05-22T10:20:08+00:00</dc:date>
    <link>https://www.businessinsurance.com/article/20210521/STORY/912341991/Chemical-firms-suffers-over-$7-million-damage-from-factory-fire</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A fire at Taiwan-based Standard Chemical & Pharmaceutical Co. Ltd.’s subsidiary in Tainan City on May 20 caused an estimated 200 million Taiwanese dollar ($7.2 million) in property losses, Focus Taiwan reported. The subsidiary Syn-Tech Chem & Pharm Co. Ltd. is also facing a fine of TWD825,000 from the city government for causing environmental pollution, as high pollutant emissions from the factory fire affected the air quality in Hsinying and Houbi districts in Tainan and neighboring Chiayi County.

]]></description>
<dc:subject>Taiwan industrial fire response drugs pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:af1f5d18d34e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Taiwan"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:drugs"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://focustaiwan.tw/society/202105200003">
    <title>Fire breaks out at Tainan pharmaceutical factory; no injuries reported</title>
    <dc:date>2021-05-20T09:38:41+00:00</dc:date>
    <link>https://focustaiwan.tw/society/202105200003</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Taipei, May 20 (CNA) A fire broke out Thursday at a factory affiliated with Standard Chem & Pharm Co. in Tainan but no injuries were reported, according to the city's fire department.

More than 100 firefighters and 51 fire engines were dispatched to battle the blaze, which covered about 100 square meters, the fire department said.

The fire started around 6:16 a.m. at a factory belonging to Syn-Tech Chem & Pharm Co., a subsidiary of Standard Chem & Pharm Co., where 50 types of chemical substances were kept on the site, according to firefighters.

As of 8:35 a.m., the fire had been brought under control and all the employees of the pharmaceutical group were reported safe, the business conglomerate said, adding that the two companies will suspend operations Thursday to tackle the aftermath of the blaze.

]]></description>
<dc:subject>Taiwan industrial fire response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:5c7a5458bdc2/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Taiwan"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/features/how-should-chemical-mixtures-be-regulated/4013604.article">
    <title>How should chemical mixtures be regulated?</title>
    <dc:date>2021-05-17T10:16:33+00:00</dc:date>
    <link>https://www.chemistryworld.com/features/how-should-chemical-mixtures-be-regulated/4013604.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[The natural environment – our air, water and soil – hosts an ever-changing cocktail of synthetic compounds originating from a wide variety of sources. Wildlife is constantly exposed to these coincidental chemical mixtures, as are humans. We are also continuously exposed to a concoction of chemicals in our indoor environments too – from chemicals leaching out of carpets, furnishings and household objects, to those coming from foods, as well as cleaning and personal care products.

This has been known for a long time. It’s also well established that exposure to chemical mixtures can cause harm – to the environment and human health – even if all the individual chemical components in the mixture are present at concentrations that would be safe if they were met alone.

This isn’t a huge surprise – mixture effects, as they’re called, are a well-known issue in pharmaceuticals. The sedative effects of some painkillers and antihistamines, for example, add together to create a larger sedative effect that each one alone. And some antibiotics render the contraceptive pill less effective.

But while the medical and pharmaceutical industries are expected to be very aware of potential issues with drug–drug interactions in patients, the chemical industry is largely not. The majority of regulative frameworks set safe exposure levels for chemicals with the assumption that the chemicals are released into a pristine location (in either the body or the environment) where no other chemicals are present. But this is not the case. Regulations may well cover intentional mixtures of chemicals, such as those in detergent or paint formulations, but not those that occur coincidentally after their intended use.

]]></description>
<dc:subject>United_Kingdom laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:9ae81f54b6cd/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.1c00015">
    <title>Use of Lithium Diisopropylamide in Flow: Operability and Safety Challenges Encountered on a Multigram Scale</title>
    <dc:date>2021-03-31T10:23:26+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.1c00015</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A workflow for the development of organometallic processes in flow was applied to synthesize 1-(5-bromopyridin-2-yl)-2-methylpropan-2-ol, a pharmaceutical intermediate. Key factors and corresponding practical assessments required for the scale-up when transferring from batch to flow are highlighted. During the rapid process development, unexpected and expected issues concerned with the use of 1 M and 2 M lithium diisopropylamide in flow were encountered and overcome as they arose. Organolithium chemistry was operated in continuous flow mode; a reaction sequence of sp3 deprotonation and in-line acetone quench, followed by a semibatch workup was scaled up to multigram quantities in a rapid, fit-for-purpose manner for early-phase project delivery.

]]></description>
<dc:subject>Spain laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:ce5ea1b5381a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Spain"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://indianexpress.com/article/cities/ahmedabad/vadodara-fire-at-petrochemical-unit-5-injured-7236898/">
    <title>Vadodara: Fire at petrochemical unit, 5 injured</title>
    <dc:date>2021-03-20T11:16:36+00:00</dc:date>
    <link>https://indianexpress.com/article/cities/ahmedabad/vadodara-fire-at-petrochemical-unit-5-injured-7236898/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[FIVE WORKERS of Shivam Petrochem Industries in Gothda village of Savli taluka of Vadodara district suffered burns after a fire broke out reportedly due to increased pressure on a reactor during a process of manufacturing a pharmaceutical chemical, officials said on Friday. A loud explosion that took place early on Friday morning was followed by a raging fire as six workers used their presence of mind to escape in the nick of time, sources said.
Four of the six employees who injured were taken to SSG hospital for treatment while two others with minor injuries received first-aid at a local hospital in Savli. The blaze from the factory was so strong that the district police diverted traffic from the Vadodara-Savli Road, which had to be closed to vehicular movement in order to allow fire tenders to bring the fire under control.
It took nearly a dozen fire tenders of the emergency department as well as other private companies nearly five hours to bring the blaze under control, and the operation continued later during the day as some sparks continued to be seen from the reactor.
]]></description>
<dc:subject>India industrial explosion injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:c40b0d7b3cf9/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.deccanchronicle.com/nation/in-other-news/120321/explosion-in-chemical-unit-two-dead-four-injured.html">
    <title>Explosion in chemical unit: two dead, four injured</title>
    <dc:date>2021-03-12T11:45:02+00:00</dc:date>
    <link>https://www.deccanchronicle.com/nation/in-other-news/120321/explosion-in-chemical-unit-two-dead-four-injured.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[KAKINADA: Two supervisors -- Kakarla Subrahmanyam (31) of Patavala Village in Tallarevu Mandal and Thotakura Venkata Ramana (37) of Mallavaram village of Tallarevu Mandal of East Godavari district -- died and four employees were wounded in an explosion in a pharmaceutical unit.

The incident occurred at Autonagar in Sarpavaram of Kakinada Rural Mandal on Thursday Afternoon.

 
The four injured -- operators Kudipudi Srinivas, Nammi Simhadri Rao and Regalla Rajkumar and Incharge deputy manager Kalaga Satya Saibaba  -- were rushed to a private hospital.

According to sources, raw material for calcium and other medicines, made out of waste from prawn, are processed in the unit with nitrofurantoin, nitric acid etc.

SP Adnan Nayeem Asmi said that when the process of mixing of nitric acid with other chemicals was on, there was a rise in temperature. A supervisor was trying to adjust the valve. Suddenly, a blast occurred. “Two supervisors died and four employees were injured,” he said.]]></description>
<dc:subject>India industrial explosion death nitric_acid pharmaceutical waste</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:f08e06824908/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:nitric_acid"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:waste"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://timesofindia.indiatimes.com/city/thane/thane-major-fire-breaks-out-at-pharmaceutical-company-in-dombivli-midc-no-injuries-reported/articleshow/80485224.cms">
    <title>Fire in Dombivli Today: Major fire breaks out at pharmaceutical company in Dombivli MIDC, no injuries reported</title>
    <dc:date>2021-01-28T11:58:40+00:00</dc:date>
    <link>https://timesofindia.indiatimes.com/city/thane/thane-major-fire-breaks-out-at-pharmaceutical-company-in-dombivli-midc-no-injuries-reported/articleshow/80485224.cms</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[KALYAN: A major fire broke out in Calyx Chemicals and Pharmaceutical Limited situated in Dombivli MIDC on Wednesday evening.
Six fire vehicles were rushed to the spot to control the blaze. The fire which broke at around 7.30pm in the record room of company, situated on the third floor, later spread onto first floor based apartment where company's research room exists.

Several chemical drums kept inside exploded. Fire brigade personnel were facing difficulties in extinguishing the fire due to lack of space to enter the company. Fire personnel later broken glass windows to make way to control fire.
Dilip Gund, chief fire officer of KDMC said, "No one is injured in the mishap as when the fire took place all employees from company managed to escape."]]></description>
<dc:subject>India industrial explosion response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:5b01a737f9e5/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.0c00467">
    <title>Explosive Hazard Identification in Pharmaceutical Process Development: A Novel Screening Method and Workflow for Shipping Potentially Explosive Materials</title>
    <dc:date>2021-01-20T11:33:03+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.0c00467</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[When a material is identified as potentially capable of explosive propagation by the Yoshida correlation, process safety scientists have few options for semiquantitatively assessing the hazards associated with the use of that material. Oxygen balance calculations, the Rule of 6, and the United Nations (U.N.) explosive functional group list are commonly employed qualitative/semiquantitative methods to assess explosivity without requiring additional experimental data. 

In contrast, a full United Nations Transportation of Dangerous Goods testing regimen requires, at a minimum, 2 kg of material for Test Series 1 alone, an excessive amount that is rarely available in early pharmaceutical development. A new assessment, called the O.R.E.O.S. method, has been developed that combines the three traditional methods for screening of explosive properties (Oxygen balance calculations, the Rule of 6, and the Explosive functional group list) with the Onset of decomposition determined by differential scanning calorimetry and the proposed Scale. 

This new assessment has been applied to known energetic materials that are flagged as potentially capable of explosive propagation by the Yoshida correlation and has been shown to be effective at classifying materials in a scale-dependent manner. The tool is customizable to fit any organization’s internal guidance on handling energetic materials. This assessment should find wide utility in both pharmaceutical development groups and contract research organizations as a means to classify compounds that may require further testing before scale-up or to steer project teams to discover safer alternatives. A brief description of the challenges associated with transporting materials for U.N. Series Testing is also presented with the aim of demystifying the process for obtaining such valuable data.

]]></description>
<dc:subject>laboratory discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:5e87265c8b31/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.newindianexpress.com/nation/2020/dec/05/maharashtra-fireman-dies-after-inhaling-hazardous-chemical-fumes-2232170.html">
    <title>Maharashtra: Fireman dies after inhaling hazardous chemical fumes- The New Indian Express</title>
    <dc:date>2020-12-05T11:34:04+00:00</dc:date>
    <link>https://www.newindianexpress.com/nation/2020/dec/05/maharashtra-fireman-dies-after-inhaling-hazardous-chemical-fumes-2232170.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[MUMBAI: A 32-year-old fireman died after he accidentally inhaled fumes of some hazardous chemical during a firefighting operation at a company in Navi Mumbai's Taloja early on Saturday, an official said.

The victim, Balu Ramu Deshmukh, belonged to the fire brigade from Ambarnath in Thane district, he said.

He was carrying out the firefighting operation along with others after a blaze erupted around 12.15 am at the company that manufactures material for pharmaceutical industry, the official said.

"Short circuit triggered the fire. As there was a huge stock of chemicals, including that of methanol, at the unit, the fire spread quickly. After being alerted, the personnel of fire brigades from Navi Mumbai, CIDCO, MIDC reached the spot," he said.

The fire brigade staff from Ambarnath also came to the site to help, the official added.

"However, during the firefighting operation Deshmukh inhaled fumes of a hazardous chemical, after which he complained of dizziness. He was then rushed to a private hospital in nearby Kamothe locality, where he died during treatment around 4.30 am," he said.

]]></description>
<dc:subject>India industrial fire death methanol pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:ec5cdae82fd3/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:methanol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.0c00226">
    <title>Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques</title>
    <dc:date>2020-10-25T11:11:27+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.0c00226</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Process safety groups in the pharmaceutical industry are important components of active pharmaceutical ingredient (API) development through its life cycle from discovery to commercial scale. The pharmaceutical process safety laboratory staff conduct a series of tests to identify chemically unstable reagents, intermediates and solvents, and mixtures to ensure that the proposed operating conditions provide a sufficient safety margin from the onset of undesired and potentially catastrophic thermal decomposition. Across several pharmaceutical companies, the methods used for these assessments and how results and conclusions are made are widespread (vide infra). A working group was created with members from several pharmaceutical companies within the International Consortium for Innovation and Quality in Pharmaceutical Development (IQ), with the goal of precompetitive collaboration and to understand each of the participating companies’ procedures and assessment regarding process safety. Each company was invited to provide input using a blind survey format. This was done in the interest of making this knowledge accessible for the participating companies and the wider community of other pharma and chemical companies and even academic institutions in the US and throughout the world. This article provides the results of this in-depth survey of the members of the IQ Consortium thermal hazard working group. General issues around different tools used to assess thermal hazard risk and questions regarding staffing and tech transfer of process safety data/information from development to manufacturing were addressed. A snapshot of how various assessment strategies are employed as a function of stage of development (early, mid, and late) is also presented.

]]></description>
<dc:subject>us industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:249a48183a4c/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.eadt.co.uk/news/chemical-spill-haverhill-1-6784611">
    <title>People are no longer urged to stay indoors due to large chemical spill in Haverhill</title>
    <dc:date>2020-08-10T11:40:48+00:00</dc:date>
    <link>https://www.eadt.co.uk/news/chemical-spill-haverhill-1-6784611</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A cordon has been lifted at a Haverhill industrial estate following a large-scale chemical incident.
Share
It happened at the site of pharmaceutical and chemical company Merck in Homefield Road at about 4.30pm today.

Suffolk Fire and Rescue Service had 10 appliances on site, and police and ambulance crews also attended, after reports of a spill involving 1,500 litres of the liquid acetonitrile, which can cause skin irritation.]]></description>
<dc:subject>United_Kingdom industrial release response acetonitrile pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:b398cc2f7507/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:release"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:acetonitrile"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/news/deadly-indian-incidents-highlight-relaxed-regulations/4012215.article">
    <title>Deadly Indian incidents highlight relaxed regulations</title>
    <dc:date>2020-07-31T11:25:51+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/deadly-indian-incidents-highlight-relaxed-regulations/4012215.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A spate of chemical accidents and emerging environmental controversies have caused concern over the consequences of India relaxing environmental and labour laws.

On 1 July a boiler explosion at Neyveli Lignite’s thermal power plant at Cuddalore, Tamil Nadu, killed 13 people and injured 17 others. This is after five were killed and three injured in another incident at the same plant in May. Five similar incidents have occurred there between 2014 and July 2020.

A fatal pre-dawn leak of styrene from LG Polymers plant in Visakhapatnam is one of several deadly incidents in recent months

On 30 June, two people died and several were injured after benzimidazole gas leaked at the pharmaceutical manufacturing company Sainor Life Sciences at Visakhapatnam. On 3 June, eight men died and 50 were injured in an explosion at a pesticide factory in Dahej, Gujarat. And on 7 May, a styrene gas leak from a plant run by South Korean firm L G Polymers, also in Visakhapatnam, claimed the lives of at least 12 people while hundreds suffered injuries.

‘Accidents happen because of routine non-compliance with general and specific conditions with impunity,’ says Gopal Krishna, director of Toxicswatch Alliance, an environmental non-profit. ‘In the name of “ease of doing business” driven by donors of ruling parties, those scientific conditions are being removed – ignoring lessons from disasters,’ he says.]]></description>
<dc:subject>India industrial follow-up death pesticides pharmaceutical styrene</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:b3c516978baf/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pesticides"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:styrene"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.thehindu.com/news/national/andhra-pradesh/four-injured-as-fire-breaks-out-in-pharma-unit/article32225241.ece">
    <title>Four injured as fire breaks out in pharma unit</title>
    <dc:date>2020-07-30T11:07:56+00:00</dc:date>
    <link>https://www.thehindu.com/news/national/andhra-pradesh/four-injured-as-fire-breaks-out-in-pharma-unit/article32225241.ece</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Four persons were injured when a fire broke out in a chemical unit at Chandrapadia village, near Vinjamur, in SPSR Nellore district in the early hours of Wednesday.


The fire extinguishing system in the pharma unit manufacturing pharmaceutical ingredients was immediately activated. The fire, which triggered a blast, was brought under control in about 30 minutes, said District Fire Officer K. Srikanth Reddy, who rushed to the spot.

The sudden increase in pressure while methanol was being loaded into the reactor caused the fire. “'The reactor has not suffered any damage,” the DFO said. The injured were rushed to a private hospital here. Later three of them in a serious condition were shifted to a hospital in Chennai for better treatment.

]]></description>
<dc:subject>India industrial explosion injury methanol pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:65df50df1f58/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:methanol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.jchemed.0c00115">
    <title>Process Safety in the Pharmaceutical Industry: A Selection of Illustrative Case Studies</title>
    <dc:date>2020-07-22T11:20:50+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.jchemed.0c00115</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Awareness of best safety practices in the industrial sector will allow students in chemistry and chemical engineering programs to apply these approaches to their own safety assessments. Process safety is a critical function within the pharmaceutical industry to ensure safety when performing reactions. An introduction to process safety and a series of case studies illustrating how safety is routinely considered within the pharmaceutical industry is presented. The concepts presented herein are applicable to multiple industries, academic research, and chemical reactions conducted on all scales. The case studies include examples where a synthesis was redesigned to afford a triazole intermediate without forming potentially explosive byproducts, an exothermic reaction was controlled by understanding the heat output with time and developing a portion-wise addition procedure, and a reaction that displayed extremely fast gas evolution was managed by using an alternative solvent and controlling the rate of reagent addition.

]]></description>
<dc:subject>United_Kingdom education discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:c7b3f3ef6097/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:education"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.duluthnewstribune.com/sports/outdoors/6576550-Endocrine-disruptors-in-lakes-are-becoming-an-emerging-concern">
    <title>Endocrine disruptors in lakes are becoming an emerging concern</title>
    <dc:date>2020-07-20T11:19:24+00:00</dc:date>
    <link>https://www.duluthnewstribune.com/sports/outdoors/6576550-Endocrine-disruptors-in-lakes-are-becoming-an-emerging-concern</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Over the past few years, studies of Minnesota’s waters have found a variety of unregulated chemicals -- such as pharmaceuticals, fragrances, fire retardants, detergents and insecticides -- which are widespread in the state’s lakes and rivers.
]]></description>
<dc:subject>us_MN public discovery environmental drugs pesticides pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:927dfd2c25b2/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MN"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:drugs"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pesticides"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://cen.acs.org/safety/industrial-safety/Industrial-chemist-Alessandro-Agosti-says/98/i22">
    <title>Industrial chemist Alessandro Agosti says quality products come from controlled, safe processes</title>
    <dc:date>2020-06-03T12:00:44+00:00</dc:date>
    <link>https://cen.acs.org/safety/industrial-safety/Industrial-chemist-Alessandro-Agosti-says/98/i22</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Integrating process safety values into organic chemical manufacturing guides Alessandro Agosti’s work each day. He is the head of process safety and reaction scale-up at Olon, an Italy-based manufacturer of pharmaceutical chemicals.

Olon’s chemists, engineers, and process safety experts help pharmaceutical companies bridge the gap from research and development to manufacturing. Agosti is an organic chemist by training and his role is to determine how pharmaceutical companies can smoothly and safely transition to plant-scale production of new chemicals.

Efficiency, high-quality products, and safe manufacturing methods go together, he says. An unsafe process is wasteful and expensive, a maxim he stresses as he scales up production for client companies.

“If you love organic chemistry, this is a dream job,” he says. “Studying reactions is never boring. They are always changing and there are always surprises, and some can become quite weird when you examine the details,” he says. In one recent case, for example, simply modifying the order in which chemicals were added to a reactor minimized impurities and drastically increased stability.

]]></description>
<dc:subject>Italy industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:885ed4758987/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Italy"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.clareecho.ie/avara-fire-heightens-chemical-concerns-at-site-post-expected-closure/">
    <title>Avara fire heightens chemical concerns at site post expected closure – The Clare Echo News</title>
    <dc:date>2020-05-15T12:35:43+00:00</dc:date>
    <link>https://www.clareecho.ie/avara-fire-heightens-chemical-concerns-at-site-post-expected-closure/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Seven units from Ennis and Shannon Fire Brigades attended an incident at the grounds of Avara Pharmaceuticals in the Shannon Industrial Estate on Sunday morning.

It is understood that the incident occured after 06:13 on Sunday morning with Shannon Fire Brigade ordered to the site at 07:02 following reports of smoke on the ground floor of a building. Ennis Fire Brigade were also mobilised to the incident as backup.

“On attendance, they met with Avara personnel, and a search of the particular building was then carried out by Fire Service personnel wearing Breathing Apparatus. It was determined that there may have been an equipment fault earlier, and the building was then declared safe by the Fire Service,” a spokesperson for Clare County Council told The Clare Echo.

The Clare Echo understands that the fire occurred due to poorly maintained equipment overheating which subsequently filled a production area with smoke, then setting off the main site evacuation alarm.


It is listed by the HSA as a notified Seveso lower tier establishment. “Major industrial accidents involving dangerous substances pose a significant threat to humans and the environment, such accidents can give rise to serious injury to people or serious damage to the environment, both on and off the site of the accident. In Europe, a catastrophic accident in the Italian town of Seveso in 1976 prompted the adoption of legislation on the prevention and control of such accidents,” a statement on the HSA’s website reads

]]></description>
<dc:subject>Ireland industrial fire response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:e347ab48dd56/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Ireland"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.newindianexpress.com/cities/hyderabad/2020/apr/27/major-fire-at-hyderabads-suven-pharma-unit-2135803.html">
    <title>Major fire at Hyderabad's Suven Pharma unit- The New Indian Express</title>
    <dc:date>2020-04-27T11:38:30+00:00</dc:date>
    <link>https://www.newindianexpress.com/cities/hyderabad/2020/apr/27/major-fire-at-hyderabads-suven-pharma-unit-2135803.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[HYDERABAD: A major fire broke out at the Suven Pharmaceutical Ltd, a pharmaceutical research and development unit, at Jeedimetla on Sunday evening. No casualties have been reported. Ten employees were inside the pharmaceutical company when the fire broke out at around 4.30 pm.

All of them escaped unhurt. Four fire tenders were pressed to control the massive flames. Jeedimetla Inspector K Balaraj said, “The fire was due to a chemical reaction inside the plant. The reactors exploded which led to the fire spreading.” All the stocks in the pharma unit were highly inflammable which is why it took a while to bring the fire under control, said Subash Reddy, Jeedimetla Station Fire Officer.

]]></description>
<dc:subject>India industrial explosion response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:4505c23e6693/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.0c00030">
    <title>Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds</title>
    <dc:date>2020-03-25T12:05:14+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.0c00030</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Fluorinated organic molecules are increasingly being prepared for a variety of applications, including pharmaceutical products. However, the supply chain to access the necessary raw materials, which originate primarily from calcium fluoride, is often not considered, may be difficult to access at commercial scale, and has become destabilized as more stringent environmental policies are justifiably enforced. This manuscript presents an overview of the preparation and use of simple organofluorinated intermediates and reagents and the challenges associated with them.]]></description>
<dc:subject>industrial discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:231ab0bb374e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://cen.acs.org/business/Chemical-firms-say-want-keep/98/i12">
    <title>Chemical firms say they want to keep going</title>
    <dc:date>2020-03-25T11:59:31+00:00</dc:date>
    <link>https://cen.acs.org/business/Chemical-firms-say-want-keep/98/i12</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[As the US government instructs citizens to follow social-distancing practices and several states mandate that residents stay home amid the COVID-19 pandemic, chemical makers continue to operate. They say they are taking measures to ensure that their workers stay safe.

A growing number of states are enacting coronavirus lockdowns that follow guidelines issued by the Department of Homeland Security listing certain workers as employed in essential, critical infrastructure. Chemical manufacturing is on the list, as are other industries—such as pharmaceuticals, medical devices, water treatment, and food and agriculture—that rely on chemicals.

Though Dow is best known for providing basic chemicals to industrial customers, many of its products make their way into critical health-care products. Dow spokesperson Kyle Bandlow draws a direct line from company operations to the battle against SARS-Cov-2, the virus that causes COVID-19.]]></description>
<dc:subject>industrial discovery environmental drugs pharmaceutical water_treatment</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:086ade691962/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:drugs"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:water_treatment"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.chas.0c00021">
    <title>Industrial Chemist Alessandro Agosti Says Quality Products Come from Controlled, Safe Processes</title>
    <dc:date>2020-03-11T12:30:35+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.chas.0c00021</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Integrating process safety values into organic chemical manufacturing guides Alessandro Agosti’s work each day. He is the head of process safety and reaction scale-up at Olon, an Italy based manufacturer of pharmaceutical chemicals.

Olon’s chemists, engineers, and process safety experts help pharmaceutical companies bridge the gap from research and development to manufacturing. Agosti is an organic chemist by training, and his role is to determine how pharmaceutical companies can smoothly and safely transition to plant-scale production of new chemicals.

Efficiency, high-quality products, and safe manufacturing methods go together, he says. An unsafe process is wasteful and expensive, a maxim he stresses as he scales up production for client companies.

]]></description>
<dc:subject>Italy laboratory discovery response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:294e91132c41/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Italy"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://mynewsla.com/education/2020/02/22/usc-pharmaceutical-student-exposed-to-toxic-chemical-hazmat-team-responds/">
    <title>USC Pharmaceutical Student Exposed to Toxic Chemical, Hazmat Team Responds</title>
    <dc:date>2020-02-23T12:06:39+00:00</dc:date>
    <link>https://mynewsla.com/education/2020/02/22/usc-pharmaceutical-student-exposed-to-toxic-chemical-hazmat-team-responds/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A graduate student at the University of Southern California Stauffer Pharmaceutical Sciences Center was exposed to a small amount of a highly toxic chemical Saturday evening and she and firefighters had to be decontaminated along with two other students, authorities said.

The exposure happened just before 7:30 p.m. at 1985 East Zonal Ave. on the USC Health Campus, said Los Angeles Fire Department spokesman Brian Humphrey.
A 24-year-old woman sustained eye exposure to a small amount of Propargylamine, a highly toxic chemical, Humphrey said. A 27-year-old man and another 24-year-old woman were in the vicinity of the exposed woman but not directly exposed to the chemical, he said.

“LAFD Hazmat experts accessed the scene and worked swiftly with other LAFD responders to carefully decontaminate all three patients, who were transported conscious and alert to a nearby hospital,” Humphrey said.
]]></description>
<dc:subject>us_CA laboratory release injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:22ec363c90d1/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_CA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:release"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.powderbulksolids.com/news/More-Than-100-Explosions-Reported-at-Chemical-Plant-02-19-2020">
    <title>More Than 100 Explosions Reported at Chemical Plant</title>
    <dc:date>2020-02-20T10:57:16+00:00</dc:date>
    <link>https://www.powderbulksolids.com/news/More-Than-100-Explosions-Reported-at-Chemical-Plant-02-19-2020</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[More than 100 explosions were reported during a major fire Tuesday afternoon at the Metropolitan Eximchem Pvt Ltd chemical plant in the Maharashtra Industrial Development Corporation (MIDC) area in Dombivli, India, according to Indian news organizations. 

Some 500 people were working in the plant when the blaze began at about 12:30 p.m. in a storage unit, coverage by the Times of India said. The facility produces intermediate chemicals for pharmaceutical and plastic production, the newspaper said. 

“Thick smoke was released since the factory manufactures 18 types of chemicals. The entire factory has been charred in the incident. There were small explosions as well,” Kalyan Dombivli Municipal Corporation (KDMC) Chief Fire Officer Dilip Gund told the Hindustan Times. “We suspect a boiler inside the plant may have also exploded due to the blaze.”

]]></description>
<dc:subject>India industrial explosion response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:20376c69587c/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.earthisland.org/journal/index.php/articles/entry/extensive-chemical-safety-fraud-uncovered-at-german-testing-laboratory">
    <title>Extensive Chemical Safety Fraud Uncovered at German Testing Laboratory</title>
    <dc:date>2020-02-18T12:01:25+00:00</dc:date>
    <link>https://www.earthisland.org/journal/index.php/articles/entry/extensive-chemical-safety-fraud-uncovered-at-german-testing-laboratory</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[The case of an animal rights activist who infiltrated an independent German chemical testing laboratory has triggered the discovery of an apparently extensive chemical testing fraud.

LPT Hamburg, with around 175 employees, is one of the largest contract laboratories in Germany. It is a family owned private company. It prepares regulatory studies on behalf of the pharmaceutical and pesticide industries and has three locations: Mienenbüttel in Lower Saxony, Neugraben in Hamburg and Wankendorf in Schleswig-Holstein.

An initial case of fraud was reported in 2019 by the German magazine FAKT, which worked with the animal rights organisations Cruelty Free International and SOKO-Tierschutz to expose the findings of the undercover employee. The disturbing irregularities they discovered included the death and replacement of animals without this being reported to authorities.]]></description>
<dc:subject>Germany laboratory discovery environmental pesticides pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:9eaee65309d5/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Germany"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pesticides"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.masslive.com/police-fire/2020/02/newburyport-chemical-manufacturing-facility-with-history-of-past-safety-violations-reopens-after-6-explosions.html">
    <title>Newburyport chemical manufacturing facility with history of past safety violations reopens after 6 explosions</title>
    <dc:date>2020-02-15T12:20:02+00:00</dc:date>
    <link>https://www.masslive.com/police-fire/2020/02/newburyport-chemical-manufacturing-facility-with-history-of-past-safety-violations-reopens-after-6-explosions.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A chemical manufacturing facility in Newburyport with a history of past environmental and safety violations reopened Friday after a series of explosions blew a hole through the roof of the building, officials said.

Authorities responded early Thursday morning to a fire alarm at 9 Opportunity Way, an industrial park where PCI Synthesis, a pharmaceutical development and manufacturing company, is located, fire officials said.


Smoke was found inside the facility, and three explosions were immediately reported, Stephen Bradbury, Newburyport deputy fire chief, said Thursday. Three more explosions occurred shortly after, and a Level 2 hazmat response was issued. Nobody was injured.

“Most of the facility was untouched and is completely operational,” PCI Synthesis said in a statement. “We want to thank the authorities for their quick work in ensuring the facility is safe and ready to re-open so that we can get back to work.”

Less than 10 employees at the facility, which operates 24 hours a day, were working at the time of the initial explosions, and multiple firefighters were in the general building. Everyone inside the building was evacuated after the first series of explosions, Newburyport Fire Chief Christopher LeClaire and City Marshal Mark Murray said in a joint statement.

]]></description>
<dc:subject>us_MA industrial follow-up environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:42d68c73a619/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.gloucestertimes.com/news/local_news/explosions-rock-port-factory/article_4deae330-93b3-5930-9279-49bb8be5af7c.html">
    <title>Explosions rock Port factory  </title>
    <dc:date>2020-02-14T11:41:24+00:00</dc:date>
    <link>https://www.gloucestertimes.com/news/local_news/explosions-rock-port-factory/article_4deae330-93b3-5930-9279-49bb8be5af7c.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[NEWBURYPORT — No one was injured after a series of explosions Thursday morning inside a pharmaceutical chemical company at Newburyport's industrial park. But the explosions inside PCI Synthesis' manufacturing plant forced the evacuation of three businesses near the Opportunity Way complex. 

Newburyport Deputy Fire Chief Stephen Bradbury said when firefighters responded to a fire alarm call around 4:30 a.m. they saw smoke inside the plant. While firefighters were investigating, three explosions took place in a different room. 

"(Firefighters) evacuated immediately," Bradbury said. 

Once they were out of the building, three more explosions occurred, ripping a 5-by-8-foot hole in the roof. 

A state hazmat team arrived and firefighters evacuated three businesses adjacent to PCI. Officials said the cause of the explosions was still under investigation Thursday afternoon. Authorities sent a robot into the area where the explosions occurred to determine whether it was safe for firefighters and others to reenter, Bradbury said. 

]]></description>
<dc:subject>us_MA industrial explosion response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:a4acd6cdf4c2/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://in.news.yahoo.com/maharashtra-govt-orders-high-level-213443166.html">
    <title>Maharashtra govt orders high-level inquiry into Tarapur factory blast</title>
    <dc:date>2020-01-17T12:28:14+00:00</dc:date>
    <link>https://in.news.yahoo.com/maharashtra-govt-orders-high-level-213443166.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[THE STATE government has instituted a high-level inquiry into last week’s blast at a chemical factory of a pharmaceutical company in Tarapur Maharashtra Industrial Development Corporation (MIDC), in which eight persons were killed.

The inquiry will be carried out by Konkan divisional commissioner, director of the Directorate of Industrial Safety and Health (DISH) and MIDC chief fire officer.

A DISH official said the probe team is awaiting reports of preliminary inquiries conducted by the local police, the Maharashtra Pollution Control Board (MPCB) and other agencies that had granted clearances and permission to operate to A N K Pharma Private Limited, where the explosion occurred just after 7 pm on January 11. “The inquiry will study the preliminary probe reports and arrive at its own conclusions on how the blast took place,” the official added.

Immediately after the blast, Chief Minister Uddhav Thackeray had ordered an audit of all chemical factories in MIDC complexes across the state.

]]></description>
<dc:subject>India industrial follow-up death pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:cd0e7eee5042/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:follow-up"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://pubs.acs.org/doi/10.1021/acs.oprd.9b00462">
    <title>Safe Scale-up of an Oxygen-Releasing Cleavage of Evans Oxazolidinone with Hydrogen Peroxide</title>
    <dc:date>2020-01-12T10:58:27+00:00</dc:date>
    <link>https://pubs.acs.org/doi/10.1021/acs.oprd.9b00462</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[In the pharmaceutical industry, H2O2-mediated oxidation reactions are commonly used in chemical syntheses but they can also introduce unexpected safety hazards. Our labs recently reported on the discovery of oxygen evolution during the LiOH/H2O2-mediated cleavage of Evans oxazolidinone. Faced with this previously unexpected hazard, the authors, herein, report on the development and demonstration of a methodology for the safe scale-up of this O2-releasing reaction. It was found that O2 in the headspace could be controlled by a combination of N2 sweeping and modulation of the LiOH addition rate. A design of experiment study was used to probe the multivariate parameter space in order to minimize formation of the unstable peracid intermediate, thus avoiding accumulation and subsequent risk of rapid and uncontrolled O2 release. To support scale-up, the well-mixed vapor headspace assumption was tested using computational fluid dynamics, and it was found that N2 sparging is effective at reducing heterogeneity in the headspace. Condenser conditions were evaluated to balance recovery of solvent—because of the high N2 sweep—and avoid the risk of condenser freezing—because of the presence of water in the condensate. An additional fail safe was developed, using a pH buffer to rapidly halt the base-catalyzed reaction in the case of an unexpectedly high headspace O2 concentration. The final process was validated and executed at up to 215 kg scale.

]]></description>
<dc:subject>industrial discovery environmental hydrogen_peroxide pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:057eaffbb07f/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:hydrogen_peroxide"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://indianexpress.com/article/cities/ahmedabad/major-fire-at-vadodara-chemical-firm-no-injuries-6116804/">
    <title>Major fire at Vadodara chemical firm, no injuries</title>
    <dc:date>2019-11-13T12:33:23+00:00</dc:date>
    <link>https://indianexpress.com/article/cities/ahmedabad/major-fire-at-vadodara-chemical-firm-no-injuries-6116804/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A major fire was reported from the godown of National Chemical company in Navayard area of Vadodara on Tuesday morning. No injuries were reported. Officials said 18 fire tenders including nine foam-based fire tenders and 60 firefighters were deployed at the site to control the situation.

Fire department officials said they had first received a call regarding smoke billowing out of the three-storeyed building at 7:24 am. But by the time the fire fighting team reached the spot, the blaze had begun engulfing the building. It took more than an hour to control the fire, and the ventilation and cooling process was still underway in the afternoon. It took 15,000 litres of foam to douse the entire fire.

The chemical company supplies raw materials to pharmaceutical companies and had built its own laboratory-cum-godown on the ground floor of the building. While it’s unknown what exactly sparked the fire, fire officials claim that it was most likely a reaction between the chemicals. “There were more than 400 different types of chemicals were stacked up on the ground floor without proper segregation. Water reactive chemicals were stacked together with flammable materials that pose high risk for fire. No guidance in terms of keeping and segregating chemicals were followed by the company, Fire officer Om Jadeja said.

“There was also a wooden partition between two floors which caught fire. Our main goal was to douse the fire at the ground floor level itself and prevent it from reaching the other floors. After the fire was contained, the main challenge was to control the smoke and fumes,” Jadeja added. A fire tender is still in place, in case of a reignition due to solvent reactions.]]></description>
<dc:subject>India laboratory fire response flammables pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:ce0e937dae6a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:laboratory"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:flammables"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.thehindu.com/news/national/andhra-pradesh/two-killed-in-explosion-at-pharma-godown/article29858617.ece">
    <title>Two killed in explosion at pharma godown</title>
    <dc:date>2019-11-02T10:21:04+00:00</dc:date>
    <link>https://www.thehindu.com/news/national/andhra-pradesh/two-killed-in-explosion-at-pharma-godown/article29858617.ece</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Two men were killed in a devastating explosion that ripped through a pharmaceutical distribution godown at a commercial complex in Seelamvari Street at Kothapet here in the early hours of Thursday. Kolagani Rama Rao, who is the proprietor of Long Live Pharmaceutical Company, and K. Madhava Rao, a local electrician, were killed in the explosion. The impact of the explosion was so severe that the entire store was gutted, the iron shutters of the adjacent shops were flattened and the thick blanket of soot was formed on the ground floor of the complex. While the cause of the explosion is not yet clear, preliminary investigation revealed that a gaseous explosion could have caused the incident which took place in a crowded commercial area in the town.

]]></description>
<dc:subject>India industrial explosion death pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:50a2941d3d33/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.epa.gov/newsreleases/newburyport-massachusetts-company-improves-chemical-safety-after-epa-settlement">
    <title>Newburyport, Massachusetts company improves chemical safety after EPA settlement</title>
    <dc:date>2019-10-03T11:56:26+00:00</dc:date>
    <link>https://www.epa.gov/newsreleases/newburyport-massachusetts-company-improves-chemical-safety-after-epa-settlement</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[BOSTON – A Newburyport, Massachusetts company that makes chemicals for the pharmaceutical industry signed an agreement with the U.S. Environmental Protection Agency (EPA) to make the company safer for employees and the environment. The settlement with Polycarbon Industries (PCI) includes a $50,210 fine and $152,000 in projects that will protect human health and the environment.

To settle charges by EPA that the company violated federal and state hazardous waste laws, PCI of 9 Opportunity Way in Newburyport agreed to buy and operate a system to monitor emissions of hazardous wastes and other gas emissions inside the manufacturing and laboratory areas of its facility. The company will also plant 63 trees in Newburyport as a Supplementary Environmental Project that will reduce air pollution in the Newburyport area.

"PCI will ensure the environment and workers are protected in the future by taking the steps needed to come into compliance," said EPA Regional Administrator Dennis Deziel. "This is important because these violations could have resulted in the release of hazardous wastes to the environment."

In its manufacturing process, PCI generates hazardous wastes such as toluene, methylene chloride, acetone and methanol. The most significant violations were that the company failed to comply with regulations designed to prevent releases of hazardous waste for four hazardous waste tanks and failed to comply with hazardous waste air emission standards for those tanks, as well as associated equipment that came into contact with the waste.]]></description>
<dc:subject>us_MA industrial discovery environmental pharmaceutical illegal</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:ddc5548957ee/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:us_MA"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:illegal"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.swindonadvertiser.co.uk/news/17930618.chemical-incident-factory-caused-emergency-evacuation/">
    <title>Catalent factory chemical incident causes emergency evacuation</title>
    <dc:date>2019-09-27T11:06:04+00:00</dc:date>
    <link>https://www.swindonadvertiser.co.uk/news/17930618.chemical-incident-factory-caused-emergency-evacuation/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Staff were evacuated after a chemical incident at a pharmaceutical factory in Swindon. 

Dorset and Wiltshire Fire Service rushed to the scene at Catalent on Frankland Road after emergency services were called at 5pm. 

A hazardous materials team along with police officers attended the scene as an investigation got underway. 

An ambulance was at the incident but no casualties were reported.

The area was cordoned off until 6.52pm. 

A spokesperson for the fire service said: "We have left the scene and we are going back tomorrow (Friday) for a further investigation on the incident."]]></description>
<dc:subject>United_Kingdom industrial release response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:217ea5ba3ad4/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:United_Kingdom"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:release"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:response"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.hindustantimes.com/cities/16-workers-injured-in-mohali-factory-blast/story-egl7RXTJ2IeZxaQb1jqfPP.html">
    <title>16 workers injured in Mohali factory blast</title>
    <dc:date>2019-08-25T13:24:33+00:00</dc:date>
    <link>https://www.hindustantimes.com/cities/16-workers-injured-in-mohali-factory-blast/story-egl7RXTJ2IeZxaQb1jqfPP.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Sixteen workers were injured — five of them critically — in a blast in a chemical reactor of a pharmaceutical company at Saidpura village in Dera Bassi subdivision of Punjab’s Mohali district on Saturday.

The firm, Nectar Lifesciences, is engaged in the production of generic drug products. The blast took place on the first floor of the plant that manufactures salts for multivitamin tablets.  

The intensity of the blast was such that a portion of the two-storey building collapsed. The factory management and the district administration are looking into its cause.

Around 28 employees were working in the plant when the mishap took place around 3:30pm.

“We heard a loud sound and saw the building collapsing amid shrieks. Soon the entire premises was filled with debris,” said Sukhwinder Singh, a tea vendor who runs his kiosk there.]]></description>
<dc:subject>India industrial explosion injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:b3bb3ac3b11e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:explosion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://cen.acs.org/safety/lab-safety/Neutrogena-recalls-acne-mask-over-concerns-about-blue-light/97/web/2019/08">
    <title>Neutrogena recalls acne mask over concerns about blue light</title>
    <dc:date>2019-08-07T11:53:39+00:00</dc:date>
    <link>https://cen.acs.org/safety/lab-safety/Neutrogena-recalls-acne-mask-over-concerns-about-blue-light/97/web/2019/08</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Last month, Neutrogena voluntarily recalled its popular Light Therapy Acne Mask, citing customer complaints of eye problems and “an abundance of caution,” according to the company. The mask targets acne-causing bacteria by irradiating skin with blue light, which sits on the more energetic end of the visible spectrum. Blue light can increasingly be found lighting up organic chemistry labs as a way to drive radical reactions. The ocular safety concerns that led to the Neutrogena recall are also inspiring chemists to find ways to protect themselves when using this popular color of light.

According to Neutrogena, adverse reactions reported by mask users included “transient eye pain or irritation, tearing, blurry vision, seeing spots, or changes in color vision” that resolved once people stopped using the mask. These reports were rare, with the company receiving complaints on about 0.02% of masks sold at the time of the recall. In a statement to C&EN, Neutrogena added that mask users with underlying eye conditions or people who are taking medications that make skin more sensitive to light, such as antibiotics like doxycycline, could theoretically be at risk for eye injuries.

Dermatologists think blue light treats acne by activating porphyrins that then produce reactive oxygen species to kill acne-causing bacteria (Drug Resist. Updat.2012, DOI: 10.1016/j.drup.2012.07.001). Similarly, blue light could damage eye cells by exciting molecules that produce destructive oxygen species, says Michael R. Hamblin, an organic chemist at the Wellman Center for Photomedicine at Massachusetts General Hospital.

]]></description>
<dc:subject>public discovery injury pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:3fe2760fd9db/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:injury"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://healthshots.hindustantimes.com/unwind/worlds-rivers-loaded-with-antibiotics-waste-study/">
    <title>World's rivers loaded with antibiotics waste: Study</title>
    <dc:date>2019-06-01T09:24:24+00:00</dc:date>
    <link>https://healthshots.hindustantimes.com/unwind/worlds-rivers-loaded-with-antibiotics-waste-study/</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Rivers worldwide are polluted with antibiotics that exceed environmental safety thresholds by up to 300 times, according to research.

Scientists found one or more common antibiotics in two-thirds of 711 samples taken from rivers in 72 countries, they told a meeting of environmental toxicologists in Helsinki.

In dozens of locations, concentrations of the drugs used to fight off bacterial infection in people and livestock exceeded safety levels set by the AMR Industry Alliance, a grouping of more than 100 biotech and pharmaceutical companies.

Ciprofloxacin, a frontline treatment for intestinal and urinary tract infections, surpassed the industry threshold at 51 of the sites tested.

At one location in Bangladesh, concentrations of another widely used antibiotic, metronidazole, were 300 times above the limit, the researchers said.]]></description>
<dc:subject>India public discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:2a876c31d3f1/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:India"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/news/japanese-professor-could-face-prison-after-teaching-students-to-make-mdma/3010417.article">
    <title>Japanese professor could face prison after teaching students to make MDMA</title>
    <dc:date>2019-04-25T09:45:41+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/japanese-professor-could-face-prison-after-teaching-students-to-make-mdma/3010417.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A professor of pharmaceutical sciences in Japan could face drugs charges after admitting he instructed students and postdoctoral researchers in his lab to make the illegal drugs MDMA and 5F-QUPIC as part of a teaching exercise.

According to a report by the Kyodo news agency, which cited anonymous sources, Tatsunori Iwamura taught around 11 students at Matsuyama University to make MDMA – the main component of ecstasy – in 2013, and 5F-QUPIC in 2018, despite not having the necessary permission from the regional government.

Police began investigating in response to a tip-off, the report says. Iwamura’s home and lab were both searched, and while no MDMA was found, traces of 5F-QUPIC were detected in the lab. When questioned by police, Iwamura acknowledged his actions were illegal, but said they were intended to aid his students’ ‘learning’.

In Japan, academics can make substances like MDMA for research purposes if they have been granted a government licence from the region hosting the research lab. The report says Iwamura did have a licence, but that it had expired and had been issued outside Ehime where Matsuyama University is based.

Iwamura’s case has been referred to prosecutors, and if charged and convicted with making the drugs illegally he could face a prison sentence of up to 10 years. The university has also said it will consider disciplinary action once the police investigation has concluded.

]]></description>
<dc:subject>Japan public discovery environmental illegal clandestine_lab pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:d9806831b462/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:Japan"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:illegal"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:clandestine_lab"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.business-standard.com/article/pti-stories/10-killed-in-fire-at-pharmaceutical-plant-in-china-119041500904_1.html">
    <title>10 killed in fire at pharmaceutical plant in China</title>
    <dc:date>2019-04-16T11:49:08+00:00</dc:date>
    <link>https://www.business-standard.com/article/pti-stories/10-killed-in-fire-at-pharmaceutical-plant-in-china-119041500904_1.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A fire tore through a pharmaceutical company in China's Shandong province on Monday, suffocating to death at least 10 persons and injuring 12 others, the fourth major industrial accident in the country since last month.

The incident occurred Monday afternoon in the basement of Qilu Tianhe Pharmaceutical when welding sparks ignited a heat-transferring substance, generating smoke, state-run Xinhua news agency reported.

Eight persons who were working on a pipeline renovation project suffocated to death on the spot, and two others died despite emergency medical treatment.

Twelve rescuers also sustained minor smoke inhalation injuries, which were not life-threatening, the report said.

]]></description>
<dc:subject>China industrial fire death pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:f01183c3fb17/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:China"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:industrial"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:fire"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:death"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.chemistryworld.com/news/why-jury-verdicts-get-overruled-in-us-industry-cancer-trials/3010372.article">
    <title>Why jury verdicts get overruled in US industry cancer trials</title>
    <dc:date>2019-04-12T11:30:22+00:00</dc:date>
    <link>https://www.chemistryworld.com/news/why-jury-verdicts-get-overruled-in-us-industry-cancer-trials/3010372.article</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Why do guilty verdicts get overruled by judges in trials linking chemical products to cancer?

High-profile lawsuits against large pharmaceutical, personal care and agrochemical companies, whose products are alleged to cause cancer, are a regular fixture in US courtrooms. Johnson and Johnson (J&J) is facing around 13,000 lawsuits relating to its talcum powder products, for example, while Bayer has assumed liability in over 11,000 cases relating to Monsanto’s glyphosate herbicide. A few years ago, Takeda and Eli Lilly faced a similar slew of suits over diabetes drug Actos (pioglitazone).

The outcomes of these trials appear to follow a familiar pattern. A jury returns a guilty verdict and awards very large damages to plaintiffs, only for the decision to be overruled by a judge, or at least the amount of damages slashed. Experts suggest that this pattern reflects the scientific complexity of the legal cases involved, and they predict that these cases will continue to be primarily appealed rather than settled.

]]></description>
<dc:subject>public discovery environmental dust pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:cb601a241f36/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:dust"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.cnn.com/2018/12/28/health/water-pharmaceutical-contaminants-epa/index.html">
    <title>Pouring drugs down the drain in hospitals</title>
    <dc:date>2019-01-01T15:08:53+00:00</dc:date>
    <link>https://www.cnn.com/2018/12/28/health/water-pharmaceutical-contaminants-epa/index.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A 2017 study titled "Drugs down the drain: When nurses object" begins with an observation: "Many times during a typical workday, American hospital nurses routinely discard unused portions of narcotics and other controlled substances into municipal water supplies." The reason this practice is routine, the authors suggest, stems from inconsistencies in regulations and how they are interpreted by hospitals.
"There are agencies at the federal, state, and local levels that have issued conflicting rules" about pharmaceutical disposal methods for hospitals, the authors wrote.
The Environmental Protection Agency strongly discourages pouring or flushing pharmaceuticals down the drain in any setting, including at health care facilities, because they may enter and pass through water treatment systems and contaminate the water supply. As part of its rule for managing hazardous waste pharmaceuticals, the EPA has banned the "sewering" (or pouring down the drain or toilet) of hazardous waste pharmaceuticals at health care facilities.]]></description>
<dc:subject>public discovery environmental pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:67919a616202/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:public"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:discovery"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:environmental"/>
	<rdf:li rdf:resource="https://pinboard.in/u:dchas/t:pharmaceutical"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.thedailystar.net/city/news/fire-rajshahi-pharma-factory-1632721">
    <title>Fire at Rajshahi pharma factory</title>
    <dc:date>2018-09-12T11:32:11+00:00</dc:date>
    <link>https://www.thedailystar.net/city/news/fire-rajshahi-pharma-factory-1632721</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[A fire broke out at the factory of Kemiko Pharmaceuticals Limited in Rajshahi city's Tikapara area yesterday, damaging its electric supply machines worth Tk 45 lakh.

The blaze was triggered at 11:45am from a transmitter blast at the factory's generator room and engulfed the building, Forhad Hossain, station officer of Rajshahi Fire Service and Civil Defence said.

However, three fire fighting units from Rajshahi Sadar, Nawhata and Rajshahi University doused the flames arrived at the scene by 11:55am with five fire trucks, and doused the fire in about 40 minutes. “We managed to save the factory's laboratory building from the fire,” he said.

]]></description>
<dc:subject>Bangladesh industrial explosion response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:6f0578147616/</dc:identifier>
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</item>
<item rdf:about="http://www.tribuneindia.com/news/chandigarh/fire-at-pharma-unit-in-mohali/615481.html">
    <title>Fire at pharma unit in Mohali</title>
    <dc:date>2018-07-06T10:21:07+00:00</dc:date>
    <link>http://www.tribuneindia.com/news/chandigarh/fire-at-pharma-unit-in-mohali/615481.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[Mohali: A fire broke out at a pharmaceutical company in Phase II, Industrial Area, here on Wednesday afternoon. According to Fire Department, two fire tenders were dispatched immediately to Ind-Swift Laboratories, a pharmaceutical company, after getting information about the incident. The incident took place on the first floor of the building at 3 pm. “The fire was controlled immediately but the thick smoke, emanating from the spot was cause of concern. We have to use dry chemical powder to control the fire due to the presence of chemicals on the premises,” said fire officials.  According to sources, around 25 employees were present there at the time of incident and all were safe. TNS
]]></description>
<dc:subject>India industrial fire response pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:aab632e52437/</dc:identifier>
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</item>
<item rdf:about="https://www.treehugger.com/clean-water/worlds-rivers-are-clogged-pharmaceutical-waste.html">
    <title>The world's rivers are clogged with pharmaceutical waste</title>
    <dc:date>2018-04-12T11:54:00+00:00</dc:date>
    <link>https://www.treehugger.com/clean-water/worlds-rivers-are-clogged-pharmaceutical-waste.html</link>
    <dc:creator>dchas</dc:creator><description><![CDATA[The next time you feel a headache coming on, take a moment before popping a painkiller and remember this: that drug will persist in the environment long after its traces have left your body. New research from the IHE Delft Institute for Water Education has found high concentrations of pharmaceuticals in river systems around the world. The research was presented to scientists at the European Geosciences Union in Vienna this week. The Guardian reports:

"A large number of drugs – analgesics, antibiotics, anti-platelet agents, hormones, psychiatric drugs, antihistamines – have been found at levels dangerous for wildlife. Endocrine disruptors, for example, have induced sex changes in fish and amphibians."
The research team, led by Dr. Francesco Bregoli, developed a method to track drug pollution hotspots, using a common anti-inflammation drug, diclofenac, "as a proxy to estimate the presence and spread of other medications in freshwater ecosystems." Bregoli and his team found that more than 10,000 kilometres (6200 miles) of rivers contain diclofenac at quantities higher than the 100 nanograms per litre limit suggested by the EU; and that veterinary use of diclofenac has led to the near-extinction of a species of vulture on the Indian subcontinent.

]]></description>
<dc:subject>public discovery environmental drugs pharmaceutical</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:dchas/b:967c035b546a/</dc:identifier>
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