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    <title>Memory Problems Today Tied to Leaded Gas Levels Half a Century Earlier | MedPage Today</title>
    <dc:date>2025-08-03T00:45:25+00:00</dc:date>
    <link>https://www.medpagetoday.com/meetingcoverage/aaic/116689?xid=nl_mpt_DHE_2025-07-27&amp;mh=7beedf85be02817127aebdf9dcc93d42&amp;zdee=gAAAAABm4vYY3ATH4iFowacPbWxqKDu5cITUhZkLc-pWE7cJHyZXCk0IubgPcT3ehIWBv65TRh84YLvoUjk40DTyydSFRhNuf3hQ3R9bIlV4bQAMMvQuEGs%253D</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>toxic exposue leaded gas long-term effects pollution air memory failing diminished impaired cognition brain unregulated human experiment health trial industrialization oil lead environment</dc:subject>
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    <title>[untitled]</title>
    <dc:date>2023-04-30T07:07:17+00:00</dc:date>
    <link>https://www.cvs.com/mcapi/immunization/documents/v2/vis-pdf?visId=879216</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>vaccine effects COVID booster bivalent</dc:subject>
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    <title>[untitled]</title>
    <dc:date>2023-04-30T07:03:14+00:00</dc:date>
    <link>https://www.cvs.com/mcapi/immunization/documents/v2/vis-pdf?visId=605946</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>vaccine effects shingles</dc:subject>
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    <title>Do you get enough zinc? Here’s how it benefits metabolic health - Levels</title>
    <dc:date>2023-03-24T15:02:04+00:00</dc:date>
    <link>https://www.levelshealth.com/blog/do-you-get-enough-zinc-heres-how-it-benefits-metabolic-health</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[According to the National Institutes of Health, the daily zinc requirements are:
Men, age 19+: 11 milligrams (mg)
Women, age 19+: 8 mg (11 mg if pregnant)
You can supplement with more zinc than the RDA since the RDA represents the minimum required amount of zinc, which may be lower than optimal zinc levels, mainly due to large-scale factors that put the general population at higher risk for zinc deficiency. Mark Hyman, MD, a Levels Advisor and best-selling author, recommends taking 30 mg daily for men and women.
The general guidance for the upper limit for zinc intake is 40 mg daily since excessive zinc intake can cause symptoms such as nausea, dizziness, headaches, and loss of appetite and is associated with high blood pressure, reduced immune function, and lower HDL cholesterol levels. Studies have also shown that very high doses of zinc from supplements (142 mg/day) may interfere with magnesium and copper absorption.]]></description>
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    <title>Aortic Pathology During COVID - 19 Pandemics. Clinical Reports in Literature and Open Questions on the two Co-Occurring Conditions</title>
    <dc:date>2023-01-09T03:37:20+00:00</dc:date>
    <link>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018903/#__ffn_sectitle</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>COVID19 cardiovascular symptoms complications effects comorbidities aortic pathology</dc:subject>
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    <title>As marijuana use grows, researchers want to know how it affects the heart | American Heart Association</title>
    <dc:date>2021-09-11T17:32:03+00:00</dc:date>
    <link>https://www.heart.org/en/news/2020/04/20/as-marijuana-use-grows-researchers-want-to-know-how-it-affects-the-heart</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Kloner said evaluating various studies conducted over the years is complicated because marijuana has become more potent. There also is the quandary that the main components of marijuana, cannabidiol (CBD) and tetrahydrocannabinol (THC), may be working at cross purposes.

For example, Kloner said, some studies suggest CBD could reduce heart rate and blood pressure, while THC – the chemical that produces euphoria – may raise heart rate and blood pressure.

"What we want to do is try to tease out the potential positive things that there could be in CBD and understand a bit more what THC is doing," he said, "and maybe come up with ways of counteracting that."

And Kloner has a warning about vaping. "Based on very recent studies, vaping of THC or marijuana, especially if it is cut with vitamin E acetate oil, should be avoided as this usage has now been associated with" lung injury and respiratory distress.]]></description>
<dc:subject>cannabis marijuana recreational medicinal use heart cardiac effects cardiovascular blood pressure overview research clinical human in vivo population</dc:subject>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:in"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:population"/>
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</item>
<item rdf:about="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/">
    <title>Curcumin: A Review of Its’ Effects on Human Health</title>
    <dc:date>2021-05-29T00:15:11+00:00</dc:date>
    <link>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664031/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Curcumin has a long established safety record. For example, according to JECFA (The Joint United Nations and World Health Organization Expert Committee on Food Additives) and EFSA (European Food Safety Authority) reports, the Allowable Daily Intake (ADI) value of curcumin is 0–3 mg/kg body weight [65]. Several trials on healthy subjects have supported the safety and efficacy of curcumin. Despite this well-established safety, some negative side effects have been reported. Seven subjects receiving 500–12,000 mg in a dose response study and followed for 72 h experienced diarrhea, headache, rash, and yellow stool [19]. In another study, some subjects receiving 0.45 to 3.6 g/day curcumin for one to four months reported nausea and diarrhea and an increase in serum alkaline phosphatase and lactate dehydrogenase contents [66].

Go to:
7. Conclusions
Curcumin has received worldwide attention for its multiple health benefits, which appear to act primarily through its anti-oxidant and anti-inflammatory mechanisms. These benefits are best achieved when curcumin is combined with agents such as piperine, which increase its bioavailability significantly. Research suggests that curcumin can help in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and subsequent performance in active people. In addition, a relatively low dose can provide health benefits for people that do not have diagnosed health conditions.]]></description>
<dc:subject>turmeric piperine drug interacton elimination benefit risk potential overview supplement spices dose dosage adverse effects review peer-reviewed research clinical human in vivo</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
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</item>
<item rdf:about="https://ctmirror.org/2019/10/10/tax-breaks-for-seniors-could-widen-gap-between-cts-rich-and-poor/">
    <title>Tax breaks for seniors could widen gap between CT's rich and poor</title>
    <dc:date>2021-03-22T08:40:12+00:00</dc:date>
    <link>https://ctmirror.org/2019/10/10/tax-breaks-for-seniors-could-widen-gap-between-cts-rich-and-poor/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>Connecticut CT tax policy effects income wealth disparity demographics aging poverty</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:f0809f689ae9/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:poverty"/>
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</item>
<item rdf:about="https://www.yourbrainonporn.com/">
    <title>Your Brain On Porn</title>
    <dc:date>2020-12-30T18:51:55+00:00</dc:date>
    <link>https://www.yourbrainonporn.com/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>porn masturbation research sex brain addiction cognitive effects</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:65d7dc74ad50/</dc:identifier>
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</item>
<item rdf:about="https://www.wsj.com/articles/doctors-begin-to-crack-covids-mysterious-long-term-effects-11604252961?mod=e2fb&amp;fbclid=IwAR3AlIGY8m_ylUMf0lsKVXpioqv5TFXdx4slhuQQy6YSbENV9MXEzVlSseQ">
    <title>Doctors Begin to Crack Covid’s Mysterious Long-Term Effects - WSJ</title>
    <dc:date>2020-12-26T01:11:44+00:00</dc:date>
    <link>https://www.wsj.com/articles/doctors-begin-to-crack-covids-mysterious-long-term-effects-11604252961?mod=e2fb&amp;fbclid=IwAR3AlIGY8m_ylUMf0lsKVXpioqv5TFXdx4slhuQQy6YSbENV9MXEzVlSseQ</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>COVID19 longhaulers longterm effects sequelae</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:805a5566cd40/</dc:identifier>
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</item>
<item rdf:about="https://www.medicinenet.com/beta-blockers_vs_arbs/article.htm#whats_the_difference_between_beta_blockers_and_arbs">
    <title>Beta-Blockers vs. ARBs for High Blood Pressure (Hypertension)</title>
    <dc:date>2020-08-09T21:50:34+00:00</dc:date>
    <link>https://www.medicinenet.com/beta-blockers_vs_arbs/article.htm#whats_the_difference_between_beta_blockers_and_arbs</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>hypertension high blood pressure low adverse effects beta angiotensin receptor blockers comparison hypotension</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:656fa035b1a2/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:hypertension"/>
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</item>
<item rdf:about="https://www.cdc.gov/tobacco/data_statistics/fact_sheets/secondhand_smoke/health_effects/index.htm">
    <title>Health Effects of Secondhand Smoke | CDC</title>
    <dc:date>2020-01-07T07:35:29+00:00</dc:date>
    <link>https://www.cdc.gov/tobacco/data_statistics/fact_sheets/secondhand_smoke/health_effects/index.htm</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[American Academy of Pediatrics, Task Force on Sudden Infant Death Syndrome. The Changing Concept of Sudden Infant Death Syndrome: Diagnostic Coding Shifts; Controversies Regarding the Sleeping Environment; and New Variables to Consider in Reducing Risk. Pediatrics 2005;116(5):1245–55 [cited 2017 Jan 11].
Centers for Disease Control and Prevention. CDC Features: Sudden Infant Death Syndrome (SIDS) [last updated 2013 Oct 25; accessed 2017 Jan 11].]]></description>
<dc:subject>tobacco smoking risks effects CDC comorbidities secondhand smoke SIDS</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:1a10ce447768/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:tobacco"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risks"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:CDC"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:comorbidities"/>
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</item>
<item rdf:about="https://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_effects/effects_cig_smoking/index.htm">
    <title>Health Effects of Cigarette Smoking | CDC</title>
    <dc:date>2020-01-07T06:59:39+00:00</dc:date>
    <link>https://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_effects/effects_cig_smoking/index.htm</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>tobacco smoking risks effects CDC comorbidities</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:d96c3cd41adb/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:tobacco"/>
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</item>
<item rdf:about="https://www.cdc.gov/tobacco/infographics/health-effects/pdfs/he-infographic1.pdf?s_cid=bb-osh-effects-graphic-005">
    <title>CDC: Risks of smoking (graphic)</title>
    <dc:date>2020-01-07T06:28:51+00:00</dc:date>
    <link>https://www.cdc.gov/tobacco/infographics/health-effects/pdfs/he-infographic1.pdf?s_cid=bb-osh-effects-graphic-005</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>tobacco smoking risks effects CDC comorbidities infographics</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:d5559a72bf56/</dc:identifier>
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</item>
<item rdf:about="https://www.cdc.gov/tobacco/infographics/health-effects/index.htm">
    <title>Health Effects Infographics | CDC</title>
    <dc:date>2020-01-07T05:42:15+00:00</dc:date>
    <link>https://www.cdc.gov/tobacco/infographics/health-effects/index.htm</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>e-cigarettes vaping tobacco smoking risks effects CDC comorbidities infographics data</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:585a12963cb4/</dc:identifier>
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</item>
<item rdf:about="https://academic.oup.com/ajcn/article-abstract/108/2/300/5051863?redirectedFrom=fulltext">
    <title>Effects of low-carbohydrate- compared with low-fat-diet interventions on metabolic control in people with type 2 diabetes: a systematic review including GRADE assessments | The American Journal of Clinical Nutrition | Oxford Academic</title>
    <dc:date>2019-05-18T20:19:08+00:00</dc:date>
    <link>https://academic.oup.com/ajcn/article-abstract/108/2/300/5051863?redirectedFrom=fulltext</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Glycated hemoglobin declined more in people who consumed low-carbohydrate food than in those who consumed low-fat food in the short term (MD: –1.38%; 95% CI: –2.64%, –0.11%; very-low-certainty evidence). At 1 y, the MD was reduced to –0.36% (95% CI: –0.58%, –0.14%; low-certainty evidence); at 2 y, the difference had disappeared. There is low to high (majority moderate) certainty for small improvements of unclear clinical importance in plasma glucose, triglycerides, and HDL concentrations favoring low-carbohydrate food at half of the prespecified time points. There was little to no difference in LDL concentration or any of the secondary outcomes (body weight, waist circumference, blood pressure, quality of life) in response to either of the diets (very-low- to high-certainty evidence).
Conclusions
Currently available data provide low- to moderate-certainty evidence that dietary carbohydrate restriction to a maximum of 40% yields slightly better metabolic control of uncertain clinical importance than reduction in fat to a maximum of 30% in people with T2D. ]]></description>
<dc:subject>triglycerides fat low diet diabetes T2D type 2 blood pressure carbohydrates carb fasting quality of life glucose carbohydrate waist circumference biomarkers peer-reviewed research human in vivo correlation effects benefit nutrition clinical trial review systematic</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:systematic"/>
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</item>
<item rdf:about="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257872/?page=1">
    <title>The vitamin A content and toxicity of bear and seal liver</title>
    <dc:date>2019-01-26T15:23:43+00:00</dc:date>
    <link>https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257872/?page=1</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>vitamin A adverse effects bear liver polar seal skin</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:96307d3a0175/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:polar"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:seal"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:skin"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.ncbi.nlm.nih.gov/pubmed/9406047">
    <title>Toxicology of melatonin. - PubMed - NCBI</title>
    <dc:date>2018-05-25T07:08:19+00:00</dc:date>
    <link>https://www.ncbi.nlm.nih.gov/pubmed/9406047</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>effects neurohormone status risk research pharmacological benefit adverse melatonin</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:374fb3144a75/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:neurohormone"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:status"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:pharmacological"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:melatonin"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://pogueman.tumblr.com/post/165518450027/pogues-basics-access-youtubes-free-music-and">
    <title>Pogue's Basics: Access YouTube's free music and... - David Pogue</title>
    <dc:date>2017-10-18T03:54:23+00:00</dc:date>
    <link>http://pogueman.tumblr.com/post/165518450027/pogues-basics-access-youtubes-free-music-and</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>production sound effects FX royalty free</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:55b96d8d2c02/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:production"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:sound"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:FX"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:royalty"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:free"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://9to5mac.com/2017/03/02/prisma-store/">
    <title>Prisma photo editing app launches store with downloadable filters, free for now | 9to5Mac</title>
    <dc:date>2017-04-22T00:54:52+00:00</dc:date>
    <link>https://9to5mac.com/2017/03/02/prisma-store/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>photo editing effects filters free</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:86fb5871e9e5/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:photo"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:editing"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:filters"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:free"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://9to5mac.com/2017/03/21/apple-clips-app-snapchat-stories-instagram/">
    <title>Apple announces Clips app that combines video, photos, music w/ animated captions &amp; effects | 9to5Mac</title>
    <dc:date>2017-03-22T04:29:40+00:00</dc:date>
    <link>https://9to5mac.com/2017/03/21/apple-clips-app-snapchat-stories-instagram/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>iOS animation video production filters effects</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:1789b70d62e6/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:iOS"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:animation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:video"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:production"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:filters"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.ncbi.nlm.nih.gov/pubmed/16184071">
    <title>A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving. - PubMed - NCBI</title>
    <dc:date>2017-03-13T18:50:08+00:00</dc:date>
    <link>https://www.ncbi.nlm.nih.gov/pubmed/16184071</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[In a small pilot trial, patients with atypical depression demonstrated significant positive therapeutic response to chromium picolinate. This finding is of interest because of the demonstrated link between depression, decreased insulin sensitivity, and subsequent diabetes and chromium picolinate's insulin enhancing effect.
METHODS:
: In this double-blind, multicenter, 8-week replication study, 113 adult outpatients with atypical depression were randomized 2:1 to receive 600 mug/day of elemental chromium, as provided by chromium picolinate (CrPic), or placebo. Primary efficacy measures were the 29-item Hamilton Depression Rating Scale (HAM-D-29) and the Clinical Global Impressions Improvement Scale (CGI-I).
RESULTS:
: Of the 113 randomized patients, 110 (70 CrPic, 40 placebo) constituted the intent-to-treat (ITT) population (i.e., received at least one dose of study medication and completed at least one efficacy evaluation) and 75 (50 CrPic, 25 placebo) were evaluable (i.e., took at least 80% of study drug with no significant protocol deviations). In the evaluable population, mean age was 46 years, 69% were female, 81% were Caucasian, and mean body mass index (BMI) was 29.7. There was no significant difference between the CrPic and placebo groups in both the ITT and evaluable populations on the primary efficacy measures, with both groups showing significant improvement from baseline on total HAM-D-29 scores during the course of treatment (p < 0.0001). However, in the evaluable population, the CrPic group showed significant improvements from baseline compared with the placebo group on 4 HAM-D-29 items: appetite increase, increased eating, carbohydrate craving, and diurnal variation of feelings. A supplemental analysis of data from the subset of 41 patients in the ITT population with high carbohydrate craving (26 CrPic, 15 placebo; mean BMI = 31.1) showed that the CrPic patients had significantly greater response on total HAM-D-29 scores than the placebo group (65% vs. 33%; p < 0.05) as well as significantly greater improvements on the following HAM-D-29 items: appetite increase, increased eating, carbohydrate craving, and genital symptoms (e.g., level of libido). Chromium treatment was well-tolerated.
LIMITATIONS:
: The study did not include a placebo run-in period, did not require minimum duration or severity of depression, and enrolled patients with major depression, dysthymia, or depression NOS.
CONCLUSIONS:
: In a population of adults with atypical depression, most of whom were overweight or obese, CrPic produced improvement on the following HAM-D-29 items: appetite increase, increased eating, carbohydrate craving, and diurnal variation of feelings. In a subpopulation of patients with high carbohydrate craving, overall HAM-D-29 scores improved significantly in patients treated with CrPic compared with placebo. The results of this study suggest that the main effect of chromium was on carbohydrate craving and appetite regulation in depressed patients and that 600 mug of elemental chromium may be beneficial for patients with atypical depression who also have severe carbohydrate craving. Further studies are needed to evaluate chromium in depressed patients specifically selected for symptoms of increased appetite and carbohydrate craving as well as to determine whether a higher dose of chromium would have an effect on mood.]]></description>
<dc:subject>carbohydrate craving chromium picolinate peer-reviewed research depression psychotropic effects .Plexus .week2</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:2ec1db848653/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:craving"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:chromium"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:picolinate"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:depression"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:.Plexus"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:.week2"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.reuters.com/article/us-eli-lilly-fda-idUSKBN13R2C3">
    <title>FDA lets Lilly cite Jardiance heart data, shares jump | Reuters</title>
    <dc:date>2016-12-07T03:18:22+00:00</dc:date>
    <link>http://www.reuters.com/article/us-eli-lilly-fda-idUSKBN13R2C3</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[At the time of approval [of Lilly's SGLT2 inhibitor Jardiance] the FDA asked that a separate trial be conducted to show the drug did not increase the risk of cardiovascular problems.

The study instead unexpectedly showed Jardiance slashed deaths by 32 percent in patients with type 2 diabetes at risk of heart attack and stroke, when added to standard diabetes medications.

It was the first time any diabetes drug was shown to reduce risk of cardiovascular death. Moreover, patients taking Jardiance had a 35 percent lower rate of hospitalization for heart failure. That information can now be included on the drug's label.

[Other SGLT2 inhibitors] include Johnson & Johnson's $1.3 billion-a-year Invokana and AstraZeneca Plc's Farxiga.

[Per @MarkHamel, Victoza has similar data.]]]></description>
<dc:subject>drug effects benefit treatment diabetes type 2 T2D cardiovascular heart risk morbidity mortality dcde</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:5cd350f0c2d6/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:treatment"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diabetes"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:type"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:T2D"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:cardiovascular"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:heart"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:morbidity"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:mortality"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:dcde"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.medscape.com/viewarticle/864498">
    <title>Intensive Glycemic Control May Harm Some Diabetes Patients</title>
    <dc:date>2016-08-29T15:24:35+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/864498</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>.T2Tight tight control diabetes type 2 drug effects risk benefit T2D treatment</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:f5cf49aa439a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:.T2Tight"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:tight"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:control"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diabetes"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:type"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:T2D"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:treatment"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.medscape.com/viewarticle/864857">
    <title>Empagliflozin Slows Progression of Renal Disease in Diabetes</title>
    <dc:date>2016-07-22T17:27:02+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/864857</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Dr Wanner noted, however, that the EMPA-REG trial lasted only 3 years, "so we are certainly looking to the future for more on this."

And both he and discussant of the findings at ADA, endocrinologist and epidemiologist, William Herman, MD, MPH, of the University of Michigan, Ann Arbor, stressed that the results are applicable only "to the population studied in the EMPA-REG trial" (ie, older patients with type 2 diabetes at high cardiovascular risk).

Currently, about a third of the population of type 2 diabetes fall into that category, Dr Herman said....

But Dr Herman pointed out in his talk that "the absolute differences are relatively small" in EMPA-REG and the number needed to treat with empagliflozin to achieve the renal benefits was 200.

In addition, it's possible that the findings "had to do with medications not administered," he said. "So it may not be a benefit of empagliflozin but the fact that those in the empagliflozin group did not receive medications causing harm [as patients in the trial were also allowed certain other standard therapies for diabetes]."

Overall, as well as the demonstrated renal effects, empagliflozin is "moderately effective" at lowering HbA1c and results in a 2- to 3-kg reduction in body weight, with no issue with hypoglycemia, although it does increase the risk of genitourinary infections, Dr Herman surmised....


"The range of cost between a generic established evidence-based oral therapy like metformin, the sulfonylureas, and now pioglitazone and the new agents is 100-fold. That is a big increase for, in some cases, a modest theoretical or practical advantage. So it's a problem for physicians and patients in the US."]]></description>
<dc:subject>kidney renal disease drug effects benefit clinical trial peer-reviewed research in vivo human NNT risk cost pharma caveat</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:efacb06ced59/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:kidney"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:renal"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:disease"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:clinical"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:cost"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:pharma"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:caveat"/>
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</item>
<item rdf:about="http://www.dlife.com/diabetes-news/viewdetailnews?news_article_id=11347569">
    <title>dLife Diabetes News - Diabetes | Type 1 Diabetes | Type 2 Diabetes - www.dlife.com</title>
    <dc:date>2016-05-19T02:39:45+00:00</dc:date>
    <link>http://www.dlife.com/diabetes-news/viewdetailnews?news_article_id=11347569</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Previous research conducted by the same researchers at Lund University in 2009 showed a gene variant to melatonin receptor 1B increases risk for type 2 diabetes. The variant causes the level of the melatonin receptors in beta cells to increase, making them more sensitive to melatonin and stopping them from secreting insulin.
"A third of all people carry this specific gene variant," Hindrik Mulder, a professor at Lund University, said in a press release. "Our results show that the effect of melatonin is stronger in them. We believe that this explains their increased risk of developing type 2 diabetes."
For the study, researchers recruited 23 healthy carriers of the gene variant and 22 people without the variant, treating them with four milligrams of melatonin before bed for three months.
The researchers found insulin secretion was lower among participants with the genetic variation, and that blood glucose levels were higher among all participants after melatonin treatment -- but most significantly in those with the variation.]]></description>
<dc:subject>genetic risk etiology factor T2D type 2 diabetes melatonin correlation peer-reviewed research circadian rhythms hormone drug effects contraindication pancreas insulin beta cells light body clock mutation genetics cause factors</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:beace043a3e7/</dc:identifier>
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</item>
<item rdf:about="http://pogueman.tumblr.com/post/142461703457/googles-giving-away-500-worth-of-photo-software">
    <title>Google’s giving away $500 worth of photo software... - David Pogue</title>
    <dc:date>2016-04-09T02:38:48+00:00</dc:date>
    <link>http://pogueman.tumblr.com/post/142461703457/googles-giving-away-500-worth-of-photo-software</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[If editing your photos means more to you than just clicking an automatic Fix button, the answer is yes. The Nik tools are complex, but they bring amazing editing power to Photoshop, Photoshop Elements, Lightroom, and Aperture as plug-ins. (You can also run the Nix apps as standalone programs, with some limitations.) In many cases, you’ll find them to be more flexible, powerful, and satisfying to use than what Adobe or Apple provides out of the box.

Get started with the nik collection

You get the software here. The videos here show you how to install it. You can find out how to run the Nik programs as standalone apps — if you don’t own Photoshop, Photoshop Elements, Lightroom, Bridge, or Aperture — here.

And this video gives a concise one-hour lesson in using all six plug-ins. If you need more, this page is full of video tutorials.]]></description>
<dc:subject>photography post-production effects</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:1d54e1448ecc/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:photography"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:post-production"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://taxpolicycenter.org/UploadedPDF/2000639-an-analysis-of-senator-bernie-sanderss-tax-proposals.pdf">
    <title>[untitled]</title>
    <dc:date>2016-03-19T23:01:05+00:00</dc:date>
    <link>http://taxpolicycenter.org/UploadedPDF/2000639-an-analysis-of-senator-bernie-sanderss-tax-proposals.pdf</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>Bernie Sanders tax plan Policy Center economic effects taxation</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:d288b7d3ca72/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Sanders"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:tax"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:plan"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Policy"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Center"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:economic"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:taxation"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.dddmag.com/articles/2015/04/strong-link-found-between-dementia-common-anticholinergic-drugs">
    <title>Strong Link Found Between Dementia, Common Anticholinergic Drugs</title>
    <dc:date>2016-01-18T16:40:32+00:00</dc:date>
    <link>http://www.dddmag.com/articles/2015/04/strong-link-found-between-dementia-common-anticholinergic-drugs</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[The group showed for the first time a dose response; that is, that Alzheimer’s risk may grow with higher use. For instance, it found people taking a minimum of 25 mg of an anticholinergic called diphenhydramine (or one Advil PM, Tylenol PM, Motrin PM, or Benadryl pill) a day for three to 12 months increased their relative risk for dementia by 19 percent; one to three years, 23 percent; three to seven years, 54 percent compared to no use (if the statistically significant increase occurred among the latter group).

Furthermore, this was the first study to find that dementias associated with anticholinergics may not be reversible even years after drug use stops. Wrote Boustani and the Indiana University Center for Aging Research’s Noll Campbell, Pharm.D., in a JAMA editorial: “The risk for dementia was consistent when comparing participants with recent and past heavy use of such medications with nonusers, suggesting that the adverse cognitive effects are permanent. Other studies have consistently shown similar results.”
....
Boustani, who is also a professor of medicine at Indiana University, told Drug Discovery & Development that, when it comes to insomnia medications, “basically any cold medications that make you sleepy might contain anticholinergics, so stay away from drugs that make you sleepy.” NyQuil is an exception, he said. It makes people sleepy, but does not contain an anti-cholinergic. Still, “if your solution for a sleep problem is a pill, a quick fix, do you want that?” Any drug taken for a long time could come with problems. “I tell people, if they have to take any such drug for more than 30 days, they should think about alternatives. Maybe you should just take it easy. Maybe you should adopt Grandma’s Remedy of hot milk, hot tea, and rest. Physical fitness is always good. Mindfulness, reflection, physical fitness, tea.”
....
Nothing is likely to be fully nailed down anytime soon as it would be unethical to do a gold standard clinical trial. Clinical trials can be done to prove benefit. But to prove a deficit would mean doctors would have to assign patients to take say, Advil PM, every night for three years to assess damage.]]></description>
<dc:subject>peer-reviewed research anticholinergic Advil Tylenol Motrin PM Benadryl drug effects risk benefit correlations Alzheimer's dementia irreversible brain tricyclic antidepressant antimuscarinics antihistamine first-generation ethics clinical trial human in vivo situ longitudinal</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:90f66b1eef59/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:anticholinergic"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Advil"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Tylenol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Motrin"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:PM"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Benadryl"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:correlations"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Alzheimer's"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:dementia"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:irreversible"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:brain"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:tricyclic"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:antidepressant"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:antimuscarinics"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:antihistamine"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:first-generation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:ethics"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:clinical"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:human"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:in"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:vivo"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:situ"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:longitudinal"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.diabeticconnect.com/diabetes-discussions/general/14208-studies-show-niacin-in-doses-of-1000mg-day-do-not-increase-insulin-resistence">
    <title>Studies Show Niacin In Doses Of 1000mg Day Do No... | Diabetic Connect</title>
    <dc:date>2015-10-18T01:05:02+00:00</dc:date>
    <link>http://www.diabeticconnect.com/diabetes-discussions/general/14208-studies-show-niacin-in-doses-of-1000mg-day-do-not-increase-insulin-resistence</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[There are two studies quoted below which state that in the dose usually prescribed for heart patients, 1,000 mg, Niacin does not result in increased insulin resistence. In fact, they say the study indicates IMPROVED control of BG.

In dose of 2,500 mg. in diabetics who have poor BG control already, it has shown some negative effects. This is good to know to avoid the higher doses, but let's not through the baby out with the bathwater on this since many of us have or will have heart related issues.

"Multiple studies were conducted to study effects of nicotinic acid on exacerbating insulin resistance. One retrospective study suggested that the use of moderate doses of extended release nicotinic acid (average, 1000 mg/d) in reasonably controlled diabetics was associated with improved glycemic control with HbA1c levels decreased by 0.5% ± 0.3% due to aggressive hypoglycemic therapy; as most of these patients had their insulin or oral diabetes regimen intensified [6]. Another retrospective study using unmodified niacin concluded similar results [7]."]]></description>
<dc:subject>niacin glucose LDL cholesterol management drug effects risk benefit</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:aaf0af112e47/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:glucose"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:LDL"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:cholesterol"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:management"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://diatribe.org/issues/68/adams-corner">
    <title>How many factors actually affect blood glucose? | diaTribe</title>
    <dc:date>2015-10-14T02:02:35+00:00</dc:date>
    <link>http://diatribe.org/issues/68/adams-corner</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[#DCDE next week will be based on this info by @asbrown1 of @diaTribeNews  - Take a look!]]></description>
<dc:subject>glucose fluctuations variations blood diabetes type 1 2 T2D management diet food exercise activity drug effects stress altitude DCDE factor etiology risk cause</dc:subject>
<dc:source>https://twitter.com/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:81fbacabf7a9/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:glucose"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fluctuations"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:variations"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:blood"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diabetes"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:type"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:1"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:T2D"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:activity"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:altitude"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:factor"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:etiology"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:cause"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://en.wikipedia.org/wiki/Fenofibrate#Adverse_effects">
    <title>Fenofibrate - Wikipedia, the free encyclopedia</title>
    <dc:date>2015-08-21T03:24:35+00:00</dc:date>
    <link>https://en.wikipedia.org/wiki/Fenofibrate#Adverse_effects</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Adverse effects[edit]
The most common adverse events (>3% of patients with coadministered statins) are[9]

Headache
Back pain
Nasopharyngitis
Nausea
Myalgia
Joint pain or arthralgia
Diarrhea
Upper respiratory tract infection
Precautions[edit]
Musculoskeletal

Myopathy and rhabdomyolysis; increased risk when coadminstered with a statin, particularly in the elderly and patients with diabetes, renal failure, hypothyroidism[9]
Hepatotoxicity

Can increase serum transaminases; liver tests should be monitored periodically[9]
Nephrotoxicity

Can increase serum creatinine levels; renal function should be monitored periodically in patients with renal insufficiency[9]
Biliary

Can increase cholesterol excretion into the bile, leading to risk of cholelithiasis; if suspected gallbladder studies are indicated. See "Interaction" section under Bile Acid Sequestrant[9]
Coagulation/Bleeding

Exercise caution in concomitant treatment with oral coumarin anticoagulants (e.g. Warfarin). Adjust the dosage of coumarin to maintain the prothrombin time/INR at desired level to prevent bleeding complications[9]]]></description>
<dc:subject>fibrates fenofibrate adverse drug effects events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:0a78452216bf/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
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</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.medicinenet.com/fibrates/page2.htm#side">
    <title>Fibrates Symptoms, Causes, Treatment - What are the side effects of fibrates? - MedicineNet - What are the side effects of fibrates?</title>
    <dc:date>2015-08-21T03:22:10+00:00</dc:date>
    <link>http://www.medicinenet.com/fibrates/page2.htm#side</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[The side effects of fibrates include nausea, stomach upset, and sometimes diarrhea. Fibrates can irritate (inflame) the liver. The liver irritation usually is mild and reversible, but it occasionally can be severe enough to require stopping the drug.

Fibrates can cause gallstones when used for several years.

Fibrates can increase the effectiveness of blood thinners, such as warfarin (Coumadin), when both medications are used together. Thus, the dose of warfarin should be adjusted to avoid over-thinning of the blood which can lead to excessive bleeding.

Fibrates can cause muscle damage particularly when taken together with statin medications. Gemfibrozil interferes with the breakdown of certain statins (for example, simvastatin [Zocor] or lovastatin [Mevacor, Altoprev]), resulting in higher statin blood levels, and hence a higher likelihood of muscle toxicity from the statin. Doctors generally avoid combining a statin with fibrates because of concern over the higher risk of muscle damage with the combination. Gemfibrozil should not be combined with simvastatin and if combined with lovastatin the dose of lovastatin should not exceed 20 mg daily. However, fenofibrate does not interfere with the breakdown of statins and should be the safer fibrate to use if it is necessary to use a fibrate with a statin. Furthermore, pravastatin (Pravachol) seems to have fewer muscle toxic effects than the other statins when combined with fibrates, but the risk still exists.]]></description>
<dc:subject>fibrates fenofibrate adverse drug effects events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:80c6e1646c5e/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fenofibrate"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:events"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.drugs.com/sfx/fenofibrate-side-effects.html">
    <title>Fenofibrate Side Effects in Detail - Drugs.com</title>
    <dc:date>2015-08-21T03:19:52+00:00</dc:date>
    <link>http://www.drugs.com/sfx/fenofibrate-side-effects.html</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[You should check with your doctor immediately if any of these side effects occur when taking fenofibrate:

Less common
Chills or fever
hives, itching, or skin rash
muscle aches and pains
nausea or vomiting
Rare
Chronic indigestion
dark urine
muscle cramps, pain, stiffness, swelling, or weakness
troubled breathing
unusual bleeding or bruising
unusual tiredness
yellow eyes or skin
Incidence not known
Agitation
bloating
bloody urine
decreased frequency or amount of urine
lower back or side pain
pains in the stomach, side, or abdomen, possibly radiating to the back
swelling of the face, fingers, or lower legs
swollen joints
upper right abdominal or stomach pain]]></description>
<dc:subject>fibrates fenofibrate adverse drug effects events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:b26d478699e8/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fibrates"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fenofibrate"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:events"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601052.html#precautions">
    <title>Fenofibrate: MedlinePlus Drug Information</title>
    <dc:date>2015-08-21T03:18:48+00:00</dc:date>
    <link>https://www.nlm.nih.gov/medlineplus/druginfo/meds/a601052.html#precautions</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Fenofibrate may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

constipation
diarrhea
heartburn
pain in the back, arm, or legs
headache
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

weakness
muscle pain or tenderness
joint pain
fever
blistering or peeling skin
rash
hives
pain in the upper back between the shoulder blades or under the right shoulder
stomach pain, especially in the upper right part of the stomach
nausea
vomiting
redness, swelling, pain, tenderness, or warmth in one leg
shortness of breath
pain when breathing
coughing up blood]]></description>
<dc:subject>fibrates fenofibrate adverse drug effects events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:553bab33e3a7/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fibrates"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fenofibrate"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:events"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.rxlist.com/fenofibrate-side-effects-drug-center.htm">
    <title>Side Effects of Fenofibrate 40 mg/ 120 mg (Fenofibrate) Drug Center - RxList</title>
    <dc:date>2015-08-21T03:18:04+00:00</dc:date>
    <link>http://www.rxlist.com/fenofibrate-side-effects-drug-center.htm</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[ Common side effects of fenofibrate include stomach pain, back pain, headache, or runny or stuffy nose. Infrequent side effects of fenofibrate include gallstones and liver problems. Call your doctor if you experience unlikely but serious side effects of fenofibrate including severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes or skin (jaundice), dark urine, unusual muscle pain, tenderness, or weakness especially if accompanied by fever or flu-like symptoms.]]></description>
<dc:subject>fibrates fenofibrate adverse drug effects events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:852decbfe04a/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fibrates"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fenofibrate"/>
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</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/">
    <title>Fiber and Prebiotics: Mechanisms and Health Benefits</title>
    <dc:date>2015-08-16T20:41:00+00:00</dc:date>
    <link>http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705355/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[The health benefits of dietary fiber have long been appreciated. Higher intakes of dietary fiber are linked to less cardiovascular disease and fiber plays a role in gut health, with many effective laxatives actually isolated fiber sources. Higher intakes of fiber are linked to lower body weights. Only polysaccharides were included in dietary fiber originally, but more recent definitions have included oligosaccharides as dietary fiber, not based on their chemical measurement as dietary fiber by the accepted total dietary fiber (TDF) method, but on their physiological effects. Inulin, fructo-oligosaccharides, and other oligosaccharides are included as fiber in food labels in the US. Additionally, oligosaccharides are the best known “prebiotics”, “a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-bring and health.” To date, all known and suspected prebiotics are carbohydrate compounds, primarily oligosaccharides, known to resist digestion in the human small intestine and reach the colon where they are fermented by the gut microflora. Studies have provided evidence that inulin and oligofructose (OF), lactulose, and resistant starch (RS) meet all aspects of the definition, including the stimulation of Bifidobacterium, a beneficial bacterial genus. Other isolated carbohydrates and carbohydrate-containing foods, including galactooligosaccharides (GOS), transgalactooligosaccharides (TOS), polydextrose, wheat dextrin, acacia gum, psyllium, banana, whole grain wheat, and whole grain corn also have prebiotic effects.]]></description>
<dc:subject>prebiotic gut health microflora flora effects food overview mechanism dietary fiber resistant starch diet peer-reviewed research clinical human in vivo</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:fa63e32dead8/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:health"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:microflora"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:flora"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:overview"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:mechanism"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:dietary"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:fiber"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:resistant"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:starch"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diet"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:in"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:vivo"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.ncbi.nlm.nih.gov/pubmed/24342746">
    <title>Efficacy and safety of a magnesium sulfate-rich natural mineral water for patients with functional constipation. - PubMed - NCBI</title>
    <dc:date>2015-08-16T18:14:11+00:00</dc:date>
    <link>http://www.ncbi.nlm.nih.gov/pubmed/24342746</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Little is known about the effects of natural mineral water on constipation in adults. We assessed the effect of a magnesium sulfate-rich natural mineral water (Hépar; Nestlé Waters, Issy-les-Moulineaux, France) on gastrointestinal transit in constipated women.

CONCLUSIONS:
In a controlled trial, daily consumption of 1 L Hépar reduced constipation and hard or lumpy stools in a greater percentage of women with functional constipation than natural low-mineral water, as early as the second week of treatment.]]></description>
<dc:subject>magnesium constipation supplements effects laxative supplement mineral water peer-reviewed research clinical human in vivo</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:f1012db55d81/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:constipation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:supplements"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:laxative"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:supplement"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:mineral"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:water"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:clinical"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:vivo"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.ncbi.nlm.nih.gov/pubmed/8878010">
    <title>The osmotic and intrinsic mechanisms of the pharmacological laxative action of oral high doses of magnesium sulphate. Importance of the release of ... - PubMed - NCBI</title>
    <dc:date>2015-08-16T18:10:29+00:00</dc:date>
    <link>http://www.ncbi.nlm.nih.gov/pubmed/8878010</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[A common use for high doses of oral magnesium salts is to produce a laxative effect to treat constipation. In the intestinal lumen the poorly absorbable magnesium ions (and other ions such as sulphate) exert an osmotic effect and cause water to be retained in the intestinal lumen. This increases the fluidity of the intraluminal contents and results in a laxative action. Although the laxative action of magnesium is thought to be due to a local effect in the intestinal tract, it is also possible that released hormones such as cholecystokinin or activation of constitutive nitric oxide synthase might contribute to this pharmacological effect. Under normal circumstances the pharmacological administration of high doses of oral magnesium salts is safe and some salts--such as magnesium hydroxide--also have an antacid effect to neutralize stomach acid. However, high doses of magnesium or prolonged use may allow sufficient absorption into the systemic circulation to cause renal or other organ toxicity.]]></description>
<dc:subject>magnesium constipation supplements risk benefit effects laxative drug peer-reviewed research clinical human in vivo</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:85930bab3d24/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:magnesium"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:laxative"/>
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</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.medicaldaily.com/chronic-teen-marijuana-use-may-not-cause-mental-health-physical-problems-after-all-345924">
    <title>Chronic Teen Marijuana Use May Not Cause Mental Health, Physical Problems After All</title>
    <dc:date>2015-08-06T20:03:07+00:00</dc:date>
    <link>http://www.medicaldaily.com/chronic-teen-marijuana-use-may-not-cause-mental-health-physical-problems-after-all-345924</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>peer-reviewed research longitudinal clinical drug effects risk benefit cannabis marijuana public health policy earnest hatmandu</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:d10ba7137fe2/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:cannabis"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:marijuana"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:public"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:policy"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:earnest"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:hatmandu"/>
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</item>
<item rdf:about="http://www.reuters.com/article/2015/07/30/us-health-accidents-adhd-medications-idUSKCN0Q42D820150730">
    <title>Medication may reduce injury risk for kids with ADHD | Reuters</title>
    <dc:date>2015-08-03T00:29:22+00:00</dc:date>
    <link>http://www.reuters.com/article/2015/07/30/us-health-accidents-adhd-medications-idUSKCN0Q42D820150730</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Children with attention-deficit hyperactivity disorder (ADHD) are less likely to have accidents that land them in the emergency room than those who are not on medication, according to a new study.

“In addition to reducing accidental injuries, the medication often is helpful in helping the child do better in school,” said Dr. James Leckman, a professor and child psychiatrist at Yale School of Medicine in New Haven, Connecticut.

“But many children with ADHD can also do well in school not on medication if the parents and teachers are aware of the issues and address them with appropriate accommodations,” said Leckman, who coauthored the new study.

ADHD medications can have unwanted side effects like trouble sleeping, anorexia, weight loss, reduced growth rates and headaches, and the decision to treat with medication needs to be a joint decision by the family and clinician, Leckman said.]]></description>
<dc:subject>ADHD treatment risk benefit trauma peer-reviewed research drug effects child health children parenting</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:2661fced208c/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:ADHD"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:treatment"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:trauma"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:child"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:health"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:children"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:parenting"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.diabeticconnect.com/diabetes-information-articles/general/1972-another-possible-use-for-metformin-reducing-risk-of-glaucoma#0">
    <title>Another Possible Use for Metformin: Reducing Risk of Glaucoma</title>
    <dc:date>2015-08-01T18:06:02+00:00</dc:date>
    <link>http://www.diabeticconnect.com/diabetes-information-articles/general/1972-another-possible-use-for-metformin-reducing-risk-of-glaucoma#0</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Another Possible Use for Metformin: Reducing Risk of Glaucoma ]]></description>
<dc:subject>metformin drug effects risk benefit glaucoma vision comorbidities diabetes T1D T2D type 1 2</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:aaec5bb772ee/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:metformin"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:glaucoma"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:vision"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:comorbidities"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diabetes"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:T1D"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:T2D"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:type"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:1"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/painkiller-linked-to-low-blood-sugar/">
    <title>Painkiller Linked to Low Blood Sugar - Diabetes Self-Management</title>
    <dc:date>2015-07-26T01:54:22+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/painkiller-linked-to-low-blood-sugar/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>drug effects adverse blood glucose peer-reviewed research</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:566334fc6c6b/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:blood"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:glucose"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://dreamscopeapp.com/create">
    <title>Dreamscope Photo Filters</title>
    <dc:date>2015-07-23T04:36:43+00:00</dc:date>
    <link>https://dreamscopeapp.com/create</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>photo manipulation effects trip automatic neural network imaging</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:8cd116c8ee55/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:photo"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:manipulation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:trip"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:automatic"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:neural"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:network"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:imaging"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://9to5mac.com/2015/06/16/adobe-integrates-stock-image-purchases-into-creative-cloud-as-it-updates-its-15-cc-apps/">
    <title>Adobe integrates stock image purchases into Creative Cloud as it updates its 15 CC apps | 9to5Mac</title>
    <dc:date>2015-06-30T04:21:13+00:00</dc:date>
    <link>http://9to5mac.com/2015/06/16/adobe-integrates-stock-image-purchases-into-creative-cloud-as-it-updates-its-15-cc-apps/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[After Effects CC now has Uninterrupted Preview to allow artists to adjust a composition’s properties and even resize panels without impacting playback. Also, the groundbreaking Adobe Character Animator brings 2D figures to life using a webcam to track facial movements, record dialog and apply movements in real time onto a pre-configured character.]]></description>
<dc:subject>animation production mocap motion capture 2D After Effects</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:1205cbb7f0f8/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:animation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:production"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:mocap"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:motion"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:capture"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2D"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:After"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Effects"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="https://mhistoire.wordpress.com/2010/02/03/mhistoire-over-there/">
    <title>M’Histoire: Over There! | M'Histoire</title>
    <dc:date>2015-06-08T02:11:37+00:00</dc:date>
    <link>https://mhistoire.wordpress.com/2010/02/03/mhistoire-over-there/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>steroid psychosis drug effects adverse events</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:af30c0a7faba/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:steroid"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:psychosis"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:events"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/metformin-and-b12-supplementation/">
    <title>Metformin and B12 Supplementation - Diabetes Self-Management</title>
    <dc:date>2015-06-05T19:55:30+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/metformin-and-b12-supplementation/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>metformin treatment drug effects adverse events risk benefit peer-reviewed research correlation in vivo human retrospective B12 supplements vitamin clinical trial</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:d4747a92424f/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:metformin"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:treatment"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:human"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:retrospective"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:B12"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:supplements"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:vitamin"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:clinical"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:trial"/>
</rdf:Bag></taxo:topics>
</item>
<item rdf:about="http://www.medscape.com/viewarticle/845232?src=wnl_edit_specol&amp;uac=123423EY">
    <title>Statins Linked to Diabetes and Complications in Healthy Adults</title>
    <dc:date>2015-06-03T23:57:54+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/845232?src=wnl_edit_specol&amp;uac=123423EY</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>statins risk benefit drug effects adverse events correlation diabetes etiology factor complications late-stage end-stage symptoms public health cause</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:db9bc7ce295e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:statins"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:benefit"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:drug"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:effects"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:adverse"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:correlation"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:diabetes"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:etiology"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:factor"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:late-stage"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:end-stage"/>
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</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/metformin-plus-gerd-meds-can-lead-to-b12-deficiency-neuropathy/">
    <title>Metformin Plus GERD Meds Can Lead to B12 Deficiency, Neuropathy - Diabetes Self-Management</title>
    <dc:date>2015-05-27T03:03:49+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/metformin-plus-gerd-meds-can-lead-to-b12-deficiency-neuropathy/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[In reviewing studies on metformin, H2RAs, PPIs, and vitamin B12 deficiency, researcher Matthew J. Zdilla, DC, found that using both metformin and one of the GERD medicines was likely to further increase a person’s chances of developing vitamin B12 deficiency and resulting neuropathy beyond the risk of using just one of these medicines....

“Metformin Plus GERD Medications Diminish Vitamin B12” Clinical Diabetes.
]]></description>
<dc:subject>metformin GERD drug effects interaction risk benefit neuropathy B12 deficiency correlation peer-reviewed research</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:8ef3bcb44c65/</dc:identifier>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:research"/>
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</item>
<item rdf:about="http://well.blogs.nytimes.com/2013/12/25/for-fitness-intensity-matters/?_php=true&amp;_type=blogs&amp;_r=2">
    <title>For Fitness, Intensity Matters - NYTimes.com</title>
    <dc:date>2015-05-23T02:30:25+00:00</dc:date>
    <link>http://well.blogs.nytimes.com/2013/12/25/for-fitness-intensity-matters/?_php=true&amp;_type=blogs&amp;_r=2</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>exercise activity fitness intensity research appetite effects peer-reviewed in vivo animal human genetic epigenetic DNA earnest clinical trial</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:b5dfb37fd365/</dc:identifier>
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</item>
<item rdf:about="http://www.diabetesincontrol.com/articles/53-diabetes-news/17944-antibiotics-possibly-linked-to-increased-risk-of-diabetes">
    <title>Antibiotics Possibly Linked to Increased Risk of Diabetes</title>
    <dc:date>2015-05-16T02:32:31+00:00</dc:date>
    <link>http://www.diabetesincontrol.com/articles/53-diabetes-news/17944-antibiotics-possibly-linked-to-increased-risk-of-diabetes</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Past treatment with 2-5 antibiotic courses shows increased #diabetes #risk.  #correlation #research #factor]]></description>
<dc:subject>correlation diabetes research factor risk etiology peer-reviewed antibiotics drug effects public health cause</dc:subject>
<dc:source>https://twitter.com/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:f0c249f7d438/</dc:identifier>
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</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/ed-medicine-reduces-diabetic-nerve-damage-in-animal-study/">
    <title>ED Medicine Reduces Diabetic Nerve Damage in Animal Study - Diabetes Self-Management</title>
    <dc:date>2015-04-08T02:51:42+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/ed-medicine-reduces-diabetic-nerve-damage-in-animal-study/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[In previous animal studies, sildenafil has been shown to improve blood supply to the sciatic nerve, which extends from the lower end of the spinal cord into the legs, and it has also been noted that people with diabetes taking the medicine have fewer symptoms of peripheral neuropathy (a type of nerve damage in the arms, legs, hands, and feet).

Many other drugs have been shown to be effective at relieving neuropathy in animal studies but have not demonstrated benefits in human trials. According to scientists at Henry Ford Hospital, this may be because these trials use young animals with an early stage of peripheral neuropathy, while most people used in studies of the condition are older and have an advanced form of peripheral neuropathy.

To better simulate the condition of participants in human trials, the researchers used 30 male mice with Type 2 diabetes that were 36 weeks old, which is roughly equivalent to middle age in people. Fifteen of the mice were given an oral dose of sildenafil every day for eight weeks, while the other fifteen mice served as a control group and were given the same amount of saline daily.

After performing a variety of nerve and function tests on both groups of mice, the researchers found that mice given sildenafil experienced noticeably improved neuropathy symptoms starting at six weeks after treatment compared with the mice that were given saline.]]></description>
<dc:subject>peer-reviewed research anecdotal evidence in vivo human animal off-label drug effects benefit neuropathy diabetic clinical trial</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:45d97a17b6b1/</dc:identifier>
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</item>
<item rdf:about="http://www.medpagetoday.com/Cardiology/Hypertension/50272?isalert=1&amp;uun=g894600d3713R7117358u&amp;xid=NL_breakingnews_2015-03-14">
    <title>Low BP Might Speed Mental Decline in Dementia | Medpage Today</title>
    <dc:date>2015-03-14T14:43:45+00:00</dc:date>
    <link>http://www.medpagetoday.com/Cardiology/Hypertension/50272?isalert=1&amp;uun=g894600d3713R7117358u&amp;xid=NL_breakingnews_2015-03-14</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Ambulatory systolic BP<128 mmHg strikingly correlates with accelerated dementia in drug-treated elders (n=172). ]]></description>
<dc:subject>blood pressure control maintenance intervention dementia risk drug effects benefit .KD cognition brain treatment dcde peer-reviewed research tight overtreatment</dc:subject>
<dc:source>https://twitter.com/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:159abc437146/</dc:identifier>
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</item>
<item rdf:about="http://www.medscape.com/viewarticle/841087">
    <title>Intranasal Oxytocin Cuts Calorie Consumption in Healthy Men</title>
    <dc:date>2015-03-12T17:04:01+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/841087</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[In response to a reporter's question about other positive effects that have recently been attributed to oxytocin, Dr Lawson said, "It's a hot hormone right now. It has social effects, improves social interactions, increases trust, and improves accurate perception of social cues. I think these effects are independent of what we're seeing."

But given that oxytocin also appears to improve anxiety and depression, which could also curb eating, she said "I think we really need to do more studies."]]></description>
<dc:subject>peer-reviewed benefit fat loss eendocrine weight neuroendocrine control effects oxytocin research hormone body maintenance</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:706c589afc14/</dc:identifier>
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</item>
<item rdf:about="http://www.medscape.com/viewarticle/840884">
    <title>Largest Risk for Diabetes With Statins Yet Seen, in New Study</title>
    <dc:date>2015-03-12T00:31:00+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/840884</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Statin therapy appears to increase the risk for type 2 diabetes by 46%, even after adjustment for confounding factors, a large new population-based study concludes.

This suggests a higher risk for diabetes with statins in the general population than has previously been reported, which has been in the region of a 10% to 22% increased risk, report the researchers, led by Henna Cederberg, MD, PhD, from the University of Eastern Finland and Kuopio University Hospital, and colleagues, who published their study online March 4 in Diabetologia.]]></description>
<dc:subject>statins risk drug benefit effects adverse in vivo human peer-reviewed research clinical trial</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:6c096de772a4/</dc:identifier>
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</item>
<item rdf:about="http://www.diabeticconnect.com/diabetes-information-articles/general/1156-fueling-debate-metformin-tied-to-low-levels-of-thyroid-stimulating-hormone#0">
    <title>Fueling Debate Metformin Tied To Low Levels Of T... | Diabetic Connect</title>
    <dc:date>2015-02-22T17:26:25+00:00</dc:date>
    <link>http://www.diabeticconnect.com/diabetes-information-articles/general/1156-fueling-debate-metformin-tied-to-low-levels-of-thyroid-stimulating-hormone#0</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>2 risk diabetes peer-reviewed drug research thyroid endocrine treatment T2D metformin type effects benefit adverse</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:142ffecc5aee/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:2"/>
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</item>
<item rdf:about="http://www.medscape.com/viewarticle/840079">
    <title>More Support for Causal Link Between Marijuana and Stroke</title>
    <dc:date>2015-02-21T14:47:54+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/840079</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[These findings align "well with epidemiological and mechanistic research on the cerebrovascular effects of cannabis," Dr Hackam notes in his article.

He says it's "striking" that more strokes are not seen given the broad use of marijuana by the general public. This could be due to variations in dosage, frequency of use, strength of marijuana (percentage of tetrahydrocannabinol), genetic susceptibility, and other drugs used with marijuana.

"It is possible that exposure is not mentioned by patients with stroke in emergency departments, or that such exposure is overlooked. Overall, however, it seems clear that physiological, clinical, and epidemiological data converge on an increased stroke risk from cannabis exposure," Dr Hackam says.]]></description>
<dc:subject>peer-reviewed earnest research effects risk drug cannabis</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:2e399540ca8e/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:peer-reviewed"/>
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</item>
<item rdf:about="http://www.diabetes.org/research-and-practice/student-resources/history-of-diabetes.html">
    <title>History of Diabetes: American Diabetes Association®</title>
    <dc:date>2015-02-21T04:42:11+00:00</dc:date>
    <link>http://www.diabetes.org/research-and-practice/student-resources/history-of-diabetes.html</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[1993

The Diabetes Control and Complications Trial (DCCT) showed that keeping blood glucose levels as close to normal as possible slows the onset and progression of eye, kidney, and nerve diseases caused by diabetes. In fact, it demonstrated that any sustained lowering of blood glucose helps, even if the person has a history of poor control.
1998

Repaglinide, brand name Prandin (Novo Nordisk) is developed. Repaglinide belongs to a class of drugs known as meglitinides. They stimulate insulin secretion in the presence of glucose.

The United Kingdom Prospective Diabetes Study (UKPDS) shows that people with type 2 diabetes who practice tight control of blood sugar levels and blood pressure levels reduce their risk of complications, similar to the results of the DCCT in people with type 1 diabetes. Together these two studies transform the nature of diabetes care around the world. [They do? - DMM]
 2008

The results of the ACCORD, ADVANCE and VADT studies are published and presented at the American Diabetes Association Scientific Sessions. All three studies fail to show a benefit of intensive glycemic control on cardiovascular outcomes in people with type 2 diabetes who are at high cardiovascular risk. The results from these studies lead to clinical recommendations that call for a more individualized approach for setting glycemic goals and treatment targets.]]></description>
<dc:subject>DCCT tight control diabetes .d2t complications late-stage symptoms risk benefit blood glucose sugar history timeline research peer-reviewed drug effects cardiovascular self-monitored self monitoring SMBG comorbidities late end-stage management treatment target range normal</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:08662e052464/</dc:identifier>
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</item>
<item rdf:about="http://www.jarrow.com/eMarketing/StrontiumFAQ_Dec9.pdf">
    <title>Strontium FAQ</title>
    <dc:date>2015-02-19T23:08:36+00:00</dc:date>
    <link>http://www.jarrow.com/eMarketing/StrontiumFAQ_Dec9.pdf</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Their surveillance of the drug during and following the trial revealed ~50% increase in annual risk of embolism and thrombosis in patients taking strontium ranelate. They also concluded that nervous system disorders are more frequent amongst strontium ranelate users:
“Especially, reports of CNS effects such as mental impairment, disturbed consciousness, memory loss/amnesia and seizures create some concern”,
and that there is
“clear impact of treatment with strontium ranelate on skeletal muscle cell integrity”,
although the clinical importance of this is unknown. The EMEA goes on to recommend that surveillance and a pharmacovigilance plan is needed for the drug (i.e.. the frequency and type of adverse events needs to be closely monitored...)]]></description>
<dc:subject>strontium supplement adverse effects risk benefit</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:fddb4472163b/</dc:identifier>
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</item>
<item rdf:about="http://www.diabeticconnect.com/diabetes-information-articles/general/1560-blood-sugar-drug-may-also-help-the-body-make-and-use-insulin#0">
    <title>www.diabeticconnect.com/diabetes-information-articles/general/1560-blood-sugar-drug-may-also-help-the-body-make-and-use-insulin?utm_source=Newsletter&amp;utm_medium=Email&amp;utm_campaign=DCN_20150207&amp;utm_term=1button#0</title>
    <dc:date>2015-02-08T20:19:17+00:00</dc:date>
    <link>http://www.diabeticconnect.com/diabetes-information-articles/general/1560-blood-sugar-drug-may-also-help-the-body-make-and-use-insulin#0</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Recent studies suggest that liraglutide may be able to help type 2 diabetics preserve the function of their pancreatic beta cells. A trial of 51 patients who had type 2 diabetes for around 2 years and an A1c of about 6% underwent 4 weeks of intensive insulin therapy followed by a daily injection of either liraglutide or a placebo. The study participants continued their trial for 48 weeks before stopping their medication and completing an oral glucose tolerance test (OGGT). An Insulin Secretion-Sensitivity Index-2 was used to measure beta cell function, and found that the liraglutide group had both a higher beta cell function and lower HbA1c. 2 weeks after stopping the study, the same differences between the two groups were no longer found.]]></description>
<dc:subject>peer-reviewed diabetes benefit insulin pancreas Victoza drug beta cell cells research protection type preservation T2D effects 2 liraglutide</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:5ad66f83bf08/</dc:identifier>
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</item>
<item rdf:about="http://www.medscape.com/viewarticle/839149">
    <title>Do Physicians Use Marijuana?</title>
    <dc:date>2015-02-08T04:15:45+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/839149</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>risk medicinal drug medicine earnest effects peer-reviewed overview benefit research cannabis hatmandu recreational use</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:c5a9bcfefbdc/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:risk"/>
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</item>
<item rdf:about="http://www.nytimes.com/2015/01/14/business/economy/the-costs-of-stinginess-in-medicaid.html?smid=tw-share&amp;_r=4&amp;referrer=">
    <title>Log In - The New York Times</title>
    <dc:date>2015-01-24T22:18:58+00:00</dc:date>
    <link>http://www.nytimes.com/2015/01/14/business/economy/the-costs-of-stinginess-in-medicaid.html?smid=tw-share&amp;_r=4&amp;referrer=</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[RT @RichmondDoc: Penny-wise, pound-foolish: The Costs of Stinginess in Medicaid  #CloseTheGap #SecureHealthcareForALL]]></description>
<dc:subject>SecureHealthcareForALL CloseTheGap Medicaid effects adoption obstruction expansion obstructionism morbidity mortality</dc:subject>
<dc:source>https://twitter.com/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:e35174e56311/</dc:identifier>
<taxo:topics><rdf:Bag>	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:SecureHealthcareForALL"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:CloseTheGap"/>
	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:Medicaid"/>
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	<rdf:li rdf:resource="https://pinboard.in/u:Michael.Massing/t:obstructionism"/>
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</item>
<item rdf:about="http://www.huffingtonpost.com/johann-hari/the-real-cause-of-addicti_b_6506936.html">
    <title>The Likely Cause of Addiction Has Been Discovered, and It Is Not What You Think | Johann Hari</title>
    <dc:date>2015-01-24T16:16:16+00:00</dc:date>
    <link>http://www.huffingtonpost.com/johann-hari/the-real-cause-of-addicti_b_6506936.html</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Bruce Alexander noticed something odd about this experiment. The rat is put in the cage all alone. It has nothing to do but take the drugs. What would happen, he wondered, if we tried this differently? So Professor Alexander built Rat Park. It is a lush cage where the rats would have colored balls and the best rat-food and tunnels to scamper down and plenty of friends: everything a rat about town could want....

In Rat Park, all the rats obviously tried both [the cocaine-laced and the undrugged] water bottles, because they didn't know what was in them....

The rats with good lives didn't like the drugged water. They mostly shunned it, consuming less than a quarter of the drugs the isolated rats used. None of them died. While all the rats who were alone and unhappy became heavy users, none of the rats who had a happy environment did.

At first, I thought this was merely a quirk of rats, until I discovered that there was -- at the same time as the Rat Park experiment -- a helpful human equivalent taking place. It was called the Vietnam War. Time magazine reported using heroin was "as common as chewing gum" among U.S. soldiers, and there is solid evidence to back this up: <strong>some 20 percent of U.S. soldiers had become addicted to heroin there, according to a study published in the Archives of General Psychiatry....
[S]ome 95 percent of the addicted soldiers -- according to the same study -- simply stopped [upon leaving Vietnam]. Very few had rehab. They shifted from a terrifying cage back to a pleasant one, so didn't want the drug any more.]]></description>
<dc:subject>peer-reviewed #hcsm environment reductionism science criticism stress earnest veterans research bad David.E compulsion distress effects Vietnam addiction hatmandu design drug hcsm</dc:subject>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:b8dba3ada7cd/</dc:identifier>
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</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/metformin-wonder-drug/">
    <title>Metformin Wonder Drug - Diabetes Self-Management</title>
    <dc:date>2015-01-10T20:31:01+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/metformin-wonder-drug/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Canadian researchers showed that metformin reduces cell mutations and DNA damage....No one thought we could limit mutations before, but perhaps metformin can do it.

A study on mice exposed to cigarette smoke showed that those given metformin had 70% less tumor growth. A small study of humans in Japan showed similar improvements in colorectal cancer outcomes. [Other] researchers write, “Women with early-stage breast cancer taking metformin for diabetes have higher response rates to [presurgical cancer therapies] than diabetic patients not taking metformin.” They also had better results than people without diabetes.
 
[Metformin works] as an antioxidant. Even better, it mainly acts on cells that are trying to turn cancerous. Gerardo Ferbeyre, MD, PhD, of University of Montreal’s Department of Biochemistry, said, “The drug seems to selectively prevent [ROS] production from … cells with [cancer-causing] mutations.”

Spanish scientists published in the journal Cell Cycle that metformin seems to block cancer in two ways. Like a chemotherapy drug, it blocks certain enzymes cancer cells need to reproduce. But the scientists wrote that metformin’s glucose-lowering and insulin-lowering effects may be more important. Metformin mimics the effect of severely restricting calories. The lowered insulin level enables healthy cells to reproduce better, so they don’t become cancerous.]]></description>
<dc:subject>David Spero metformin liver drug effects blood glucose glycogen action insulin resistance antioxidant prevention cancer mutation protective risk benefit antimutagenic</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:b6a1447190c9/</dc:identifier>
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</item>
<item rdf:about="http://www.diabetesselfmanagement.com/blog/diabetes-metformin-and-your-liver/">
    <title>Metformin, the Liver, and Diabetes - Diabetes Self-Management</title>
    <dc:date>2015-01-10T20:25:55+00:00</dc:date>
    <link>http://www.diabetesselfmanagement.com/blog/diabetes-metformin-and-your-liver/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Metformin takes a couple of hours to fully absorb, and lasts about five hours in most people. (Half-life in the body is about six hours.) There is also an extended release form that can be taken once or twice a day.

What causes leaky livers[—those that convert too much glycogen to glucose, and do not respond to insulin regulation—]in the first place is not really known. It seems that people with fatty livers may be up to five times as likely to develop diabetes, so liver fat, which is loosely associated with abdominal fat, may be part of the story. But thin people can have leaky livers, too, so there’s more to it.

It might help to learn when your liver tends to dump sugars. This might require frequent monitoring for a while. Jim has a continuous glucose monitor, which enabled him to get his regime right. According to him, if his sugar goes low, or his metformin level goes low, or sometimes after eating (for some unknown reason), his liver will dump glucose into his bloodstream, as he can see on his monitor. The only thing that stops it is having enough metformin in his system.

]]></description>
<dc:subject>metformin liver drug effects blood glucose glycogen CGM circadian action insulin resistance David Spero rhythms leaky actionable data prevention SMBG</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:57f0f60e29ed/</dc:identifier>
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</item>
<item rdf:about="http://www.medscape.com/viewarticle/836490">
    <title>Is Niacin Done?</title>
    <dc:date>2014-12-20T19:27:07+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/836490</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[Despite the better lipid profiles, those on niacin did not have better outcomes and no significant reduction in major vascular events. That is not all the bad news for those taking niacin. They also had more adverse events way beyond flushing: more myopathy, which was 10 times more likely in Chinese participants compared with those of European descent; more bleeding, including gastrointestinal bleeding and bleeding in intracranial and other sites; more diabetes—new diabetes diagnoses were increased by a third. And very surprising and unexpected: There was also an excess of serious infections in the niacin group.

So, not only did niacin not significantly reduce the risk for major vascular events, but the risk for serious adverse events was greatly increased.

As Donald Lloyd-Jones says in his accompanying editorial, it is time to face facts. For niacin and vascular effects, there is a consistent lack of benefit. 
[adding emphasis—DMM:]
Perhaps HDL-C level is a risk marker rather than a risk factor.]]></description>
<dc:subject>HDL niacin PLAY video risk marker factor drug supplement effects diabetogenic diabetes etiology adverse events bleeding cardiovascular infection myopathy lipids blood muscular cause</dc:subject>
<dc:source>https://pinboard.in/</dc:source>
<dc:identifier>https://pinboard.in/u:Michael.Massing/b:86bb9adadc90/</dc:identifier>
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<item rdf:about="http://www.medscape.com/viewarticle/832841">
    <title>Statins: The Good, the Bad, and the Unknown</title>
    <dc:date>2014-10-18T15:22:54+00:00</dc:date>
    <link>http://www.medscape.com/viewarticle/832841</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[In July, Medscape posted "Growing Doubt on Statin Drugs: The Problem of Drug-Lifestyle Interaction," a perspective by cardiac electrophysiologist Dr John Mandrola about the value of statin medications in primary prevention for cardiovascular disease (CVD). The driver for his article was a recent experience in which he treated a patient's myalgia and arthralgia by discontinuing her statin. Dr Mandrola had no qualms about stopping the statin, citing a lack of data supporting a significant benefit for these drugs in primary prevention.

The commentary generated more than 600 responses from Medscape readers, a substantial majority of whom agreed with his viewpoint....]]></description>
<dc:subject>statins risk drug effects adverse benefit</dc:subject>
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    <title>Heavy pot use in teen years may predict later-life disability - Yahoo News</title>
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    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[MT Omitting "heavy" misrepresents conclusions. @UF_Rehab_DOCE: Marijuana usage may lead to disability later in life. ]]></description>
<dc:subject>research marijuana recreational cannabis peer-reviewed drug effects in vivo human large cohort Sweden conscripts correlation earnest clinical trial</dc:subject>
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    <title>If It's Not Broke, Don't Fix It - Defining Polypharmacy | Med Ed 101</title>
    <dc:date>2014-08-04T16:59:35+00:00</dc:date>
    <link>http://www.meded101.com/broke-dont-fix-it-defining-polypharmacy/</link>
    <dc:creator>Michael.Massing</dc:creator><dc:subject>polypharmacy aging treatment assessment drug effects criticism management analysis</dc:subject>
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<item rdf:about="http://lowninstitute.org/news/blog/editorial-defending-good-science/">
    <title>Editorial: Defending Good Science  –  Lown Institute</title>
    <dc:date>2014-07-23T14:15:35+00:00</dc:date>
    <link>http://lowninstitute.org/news/blog/editorial-defending-good-science/</link>
    <dc:creator>Michael.Massing</dc:creator><description><![CDATA[RT @HeartSisters: Bullying the BMJ: "Statins reduce the risk of death only for patients at highest risk"  @lowninstitute]]></description>
<dc:subject>statins risk drug effects</dc:subject>
<dc:source>https://twitter.com/</dc:source>
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