https://pinboard.in/u:Michael.Massing/public/ recent bookmarks from Michael.Massing 2023-11-15T20:21:39+00:00 https://9to5mac.com/2023/11/14/withings-launches-body-pro-2-diabetes-detection/ Michael.Massinghealth gadgets devices monitor risk diabetes diabetic complications scale feet https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:e9ce0051cdc1/ 2023-06-21T06:49:32+00:00 https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/diabetes-in-america-3rd-edition Michael.Massinginsulin type 2 diabetes T2D treatment exogenous medication https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:6f6759132d19/ 2023-06-20T19:06:17+00:00 https://www.accu-chek.com/life/travel-diabetes?XID=1d19e6c78182f10864a3d943549b47b8528e444a2c41692c190590232fbd7468&contactid=003b0000011F9YsAAK Michael.Massingdiabetes travel https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:4159e315e9c0/ 2023-04-29T18:28:09+00:00 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Importantly, in this first and largest meta-analysis reviewing LVEF >50%, we show that this benefit is maintained, albeit to a lesser degree, in the cohort of patients with LVEF ≥50%. SGLT2i become in this way the first medication with potential for prognostic benefit in HFpEF. However, overall mortality was not improved in HFpEF, indicating that the other comorbidities associated with HFpEF play a significant role. In order to draw robust conclusions safely regarding these efficacy outcomes, further large trials need to evaluate the effect of the SGLT2 inhibitors in a sufficient number of patients with HFpEF. The various subphenotypes of HFpEF and its management have puzzled physicians for several years. The high rates of morbidity and mortality that it carries, along with the diagnostic and treatment challenges, have transformed it in one of the most challenging clinical entities. SGLT2i appear to provide some light and positivity, as their cardiometabolic profile impacts favourably on the complex pathophysiological mechanisms involved in HFpEF.9 However, the quest to untangle the complexity of treating HFpEF is certainly not over. We show conclusively that for LVEF 40–50% included as HFpEF in previous studies (but no longer considered HFpEF in the guidelines) there is a strong benefit from SGLT2i translating to reduced cardiovascular mortality and HHF, but not overall mortality. This also extended to the LVEF >50% but with a smaller effect. Additionally, while the vast majority of the patients included in this meta-analysis were individuals with diabetes at baseline, the cardioprotective benefits of the SGLT2i have been shown to occur via mechanisms independent of baseline diabetes status.10 Furthermore, the effect of SGLT2i in patients with reduced EF without diabetes is well-documented9,10 and EMPEROR-Preserved also included patients without diabetes, therefore their effect is applicable to patients without diabetes.]]> SGLT2 inhibitor risk benefit heart failure ejection fraction meta-analysis diabetes comorbidity cardiac cardiovascular protection peer-reviewed research https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:c3be4a0be53b/ 2021-10-25T04:17:24+00:00 https://www.diabetesresearchclinicalpractice.com/action/showPdf?pii=S0168-8227%2821%2900008-5 Michael.Massing diabetes language stigma position statement Australia clinical education bedside manner https://pinboard.in/ 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Mayo Clinic https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:fc2a14081741/ 2021-06-12T03:26:19+00:00 https://diabeteswise.org/check-up/#/ Michael.Massingdiabetes supplies tech meter pump comparison CGM sensors insulin injections MDI https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:71b6fc77ad8a/ 2021-05-06T07:05:29+00:00 https://twitter.com/Type2andYouCDE/status/1204404950194950144/photo/1 Michael.Massing perspective TuesdayThoughts dsma diabetes https://twitter.com/ https://pinboard.in/u:Michael.Massing/b:ab514da07d37/ 2021-04-11T21:46:23+00:00 http://twicediabetes.com/cheating-lies-hcps-tell/#more-72 Michael.Massingdiabetes cheating lies propaganda expectations patients providers doctors https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:d39215b918f3/ 2021-04-06T03:57:47+00:00 https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/217393 Michael.Massing diabetic ketoacidosis DKA diagnosis type 1 diabetes T1D trends incidence prevalence peer-reviewed research hospitalization human retrospective cohort vulnerability susceptibility correlation in vivo situ 2 T2D emergency crisis https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:5fe627671df5/ 2021-04-06T03:40:18+00:00 https://www.cdc.gov/mmwr/volumes/67/wr/mm6712a3.htm Michael.Massing diabetic ketoacidosis DKA diagnosis type 1 diabetes T1D age trends incidence prevalence peer-reviewed research hospitalization human retrospective cohort vulnerability susceptibility correlation emergency crisis https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:ad19c098ac31/ 2021-04-05T04:07:31+00:00 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357617/ Michael.Massingdiabetic ketoacidosis DKA diagnosis type 1 diabetes T1D Italy children peer-reviewed research in vivo situ hospitalization human retrospective cohort insurance correlation emergency crisis https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:26dac5c5ece7/ 2021-04-05T04:05:19+00:00 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3215499/ Michael.Massingdiabetic ketoacidosis DKA diagnosis type 1 diabetes T1D Iran children peer-reviewed research in vivo situ hospitalization human retrospective cohort insurance correlation emergency crisis https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:64679032977c/ 2021-04-05T04:04:07+00:00 https://link.springer.com/article/10.1007/s00125-012-2690-2 Michael.Massingdiabetic ketoacidosis DKA diagnosis type 1 diabetes T1D international comparison systematic review children peer-reviewed research in vivo situ hospitalization human retrospective cohort insurance correlation emergency crisis https://pinboard.in/ https://pinboard.in/u:Michael.Massing/b:ba27906b807d/ 2021-04-05T04:02:19+00:00 https://care.diabetesjournals.org/content/43/1/117 Michael.Massingdiabetic ketoacidosis DKA diagnosis type 1 diabetes T1D Colorado children peer-reviewed research in vivo situ hospitalization human retrospective cohort nsurance correlation 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